Tests how each blocked heart artery causes chest pain in people with angina
Studies which narrowed heart arteries cause chest pain in adults with several blocked arteries.
Plain-language title generated from the registry record
Registry title: Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Key facts
- Where
- Basildon, Bournemouth, Brighton, London, Portsmouth, and Southampton, United KingdomSee the 8 sites
Where in United Kingdom
- Essex Cardiothoracic CentreBasildon, United KingdomTaking people
- Royal Bournemouth HospitalBournemouth, United KingdomTaking people
- Royal Sussex County HospitalBrighton, United KingdomTaking people
- Imperial College NHS TrustLondon, United KingdomTaking people
- Royal Free London NHS Foundation TrustLondon, United KingdomTaking people
- St Georges University HospitalLondon, United KingdomTaking people
- Portsmouth Hospitals University NHS TrustPortsmouth, United KingdomNot yet recruiting
- University Hospital SouthamptonSouthampton, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imperial College London
- Trial code
- NCT06400290
- Record updated
- 28 October 2026
- Original description
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 50 patients with multi-vessel coronary artery disease.Read full original descriptionShow less
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 50 patients with multi-vessel coronary artery disease.
Inclusion: Eligibility for PCI due to angina; Anatomical evidence of significant multi-vessel coronary stenosis defined by either:; ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA); Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA; Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:; dobutamine stress echocardiogram; cardiac MRI; myocardial perfusion study; CT-FFR; invasive metrics of coronary physiology.
Exclusion: Previous coronary artery by-pass graft surgery (CABG); Contraindication to PCI or a drug-eluting stents; Contraindication to antiplatelet therapy; Recent acute coronary syndrome; Significant left main stem disease; Moderate to severe valvular disease; Moderate to severe left ventricular impairment; Chronic total occlusion in the target artery(s); Contraindication to adenosine; Pregnant; Inability to consent.