Optimal Intervention to Full Viral Suppression: Text Me, Alexis!
Key facts
- Who runs it
- Friends Research Institute, Inc.
- Where
- Los Angeles, United StatesSee the site
- Trial code
- Status
- Terminated
- People taking part
- 71 people enrolled
- Started
- 11 Apr 2024
- Ended
- 19 Mar 2025
- Type of study
- Interventional, 3 groups
- Treatments tested
- Text Me, Alexis!
- Record updated
- 2 September 2026
- Why it stopped
- President Trump's Executive Order
Who can take part
- Age
- 18 years and older
- Sex
- Men only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Self-identified transgender woman
- Age 18 or older
- Verified HIV positive status
- Not currently in HIV care, and/or had not had an HIV care visit in the previous 6 months, and/or had a viral load of ≥200 copies/ml on her last lab test result, and/or not currently prescribed ART, and/or prescribed ART but does not rate her ability to take all her medications as "excellent"
- Ability to receive daily text messages on either a personal cell phone or via an email account
Who cannot take part
- Currently in HIV care, and had a HIV care visit in the previous 6 months, and had a viral load of ≤200 copies/ml on her last lab test result, and currently prescribed ART, and rates her ability to take all her medications as "excellent"
- HIV negative status
- Under 18 years of age
- Does not identify as a transgender woman
- Does not have the ability to receive daily text messages on either a personal cell phone or via an email account
Where in United States
- Friends Community CenterLos Angeles, United States
About the trial
What the trial wants to find out
Text Me, Alexis! is a three-arm randomized controlled trial (RCT) to determine the optimal and most cost-effective intervention for advancing trans women living with HIV to full viral suppression. Participants will be randomized (1:1:1) to Peer Health Navigation (PHN) alone, SMS (text messaging) alone, or PHN+SMS. Participants in the PHN alone and PHN+SMS arms will receive unlimited navigation sessions over 3 months. Participants in the SMS alone and PHN+SMS arms will receive 3 daily theory-based text messages for 90 days for a total of 270 unique scripted messages.
The 3 groups in the trial
- Peer Health Navigation (PHN)Treatment being tested
PHN is a peer navigation intervention to advance trans women through the HIV Care Continuum by identifying their individual needs and barriers to HIV care, including: substance use and behavioral health needs; adherence goal(s); and methods to achieve adherence. Participants receive unlimited navigation sessions over 3 months; PHN sessions are delivered in a private room similar to a one-on-one peer counseling session.
Treatment: Text Me, Alexis!
- Simple Message System (SMS [text messaging])Treatment being tested
Text messages are scripted across: 1) HIV Care Continuum (HIV Positivity/Physical and Emotional Health, Linkage/Retention in HIV Care, and ART Adherence/Viral Load Suppression); and, 2) theoretical foundation (Social Support Theory, Social Cognitive Theory, or Health Belief Model). Participants receive three daily, theory-based text messages for 90 days (270 unique scripted messages), evenly arrayed across the HIV Care Continuum. Text messages are delivered and transmitted to either a cell phone or an email inbox.
Treatment: Text Me, Alexis!
- PHN and SMSTreatment being tested
PHN + SMS is the combined intervention. PHN is a peer navigation intervention to advance trans women through the HIV Care Continuum by identifying their individual needs and barriers to HIV care, including: substance use and behavioral health needs; adherence goal(s); and methods to achieve adherence. Participants receive unlimited navigation sessions over 3 months; PHN sessions are delivered in a private room similar to a one-on-one peer counseling session. Text messages are scripted across: 1) HIV Care Continuum (HIV Positivity/Physical and Emotional Health, Linkage/Retention in HIV Care, and ART Adherence/Viral Load Suppression); and, 2) theoretical foundation (Social Support Theory, Social Cognitive Theory, or Health Belief Model). Participants receive three daily, theory-based text messages for 90 days (270 unique scripted messages), evenly arrayed across the HIV Care Continuum. Text messages are delivered and transmitted to either a cell phone or an email inbox.
Treatment: Text Me, Alexis!
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparative- and Cost-effectiveness Research Determining the Optimal Intervention for Advancing Transgender Women Living With HIV to Full Viral Suppression
- Record updated
- 2 September 2026