NCT06409624Recruiting
Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
Association Between Biomarkers and Kidney Function Decline in Patients With Pulmonary Hypertension
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 7 May 2024
- Start date
- 31 May 2024
- Primary completion date
- Oct 2027
- Lead sponsor
- University of Giessen
- NCT number
- NCT06409624
What you commit to
- Study type: Observational
- Planned participants: 400
- From 31 May 2024 to the primary completion date, Oct 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- if they had received non-steroidal anti-inflammatory drugs or intravenous contrast within 72 hours before RHC
- solid organ transplantation
- likelihood of receiving advanced therapy (mechanical circulatory assist device/lung or cardiac transplant)
Other illness
- active tumor disease requiring targeted therapy
- inflammatory or autoimmune disease with renal involvement requiring systemic immunosuppressive treatment
- non-kidney failure requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload
- polycystic kidney disease
Lab values
- unexplained kidney function decline, defined as serum creatinine increase ≥0.5 mg/dL from baseline within the prior 7 days before RHC
- Chronic kidney disease with eGFR \<20 ml/min/1.73 m2
Other
- multifactorial or indeterminate PH, for which no single underlying mechanism could be reliably classified
- prediagnosed glomerulonephritis
- postrenal obstruction
- single kidney (functional or anatomical)
- anticipated life expectancy of \<12 months
- pregnancy or possibility of pregnancy in the next 12 months
- inability to cooperate with respiratory maneuvers during renal Doppler
- refusal to participate
- not available for follow-up visits
Who the study is looking for
- Inpatients aged ≥18 years
- Undergoing right heart catheterization (RHC)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kerckhoff Klinik Heart and Thorax Center Coordinator of this site? Confirm its status | Bad Nauheim | Germany | Recruiting |
| University Hospital Giessen and Marburg, Campus Giessen, Department of Internal Medicine II Coordinator of this site? Confirm its status | Giessen | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.