Retinal Vessel Leakage in People With Small Brain Vessel Disease
Uses eye imaging with fluorescent dye to study leaking vessels in small brain vessel disease.
Plain-language title generated from the registry record
Registry title: Retinal Vessel Leakage in Cerebral Small Vessel Disease
Key facts
- Where
- Edinburgh, United KingdomSee the site
Where in United Kingdom
- NHS LothianEdinburgh, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Edinburgh
- Trial code
- NCT06416371
- Record updated
- 4 March 2026
- Original description
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are:Read full original descriptionShow less
Retinal Vessel Leakage in Cerebral Small Vessel Disease: a Sub-study of the Mild Stroke Study 3
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are:
* Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally?
Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels.
Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.
Inclusion: Membership in the Mild Stroke Study 3 cohort; Contrast enhanced MRI within 12 months; Clear optical media in both eyes, as assessed by study investigator; Best corrected visual acuity (near vision) ≥N36.
Exclusion: Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF); Recent eye surgery; Pregnancy, renal failure; Severe dementia; Known allergy to fluorescein; History of allergy such as food or drug induced urticaria or history of bronchial asthma; Any other severe or acute medical or psychiatric conditions; Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension); Shallow anterior chambers as assessed by torch test; Inability to give informed consent.