Studies how the spleen handles blood cells, using tissue removed during surgery
Studies spleen tissue and blood from adults who have their spleen removed.
Plain-language title generated from the registry record
Registry title: Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Key facts
- Where
- Clichy and Paris, FranceSee the 5 sites
Where in France
- Hopital BeaujonClichy, FranceTaking people
- Hopital Necker Enfants MaladesParis, FranceTaking people
- Hopital Pitie-SalpetriereParis, FranceTaking people
- Hôpital Saint-AntoineParis, FranceTaking people
- Institut PasteurParis, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT06418256
- Record updated
- 15 September 2025
- Original description
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).Read full original descriptionShow less
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).
Inclusion: Adult patients; Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication.
Exclusion: The patient notified his doctor of his refusal to recover his spleen and blood volume.