Fish Oil, Metformin and Heart Health in PCOS
Key facts
- Where
- Edmonton, CanadaSee the 3 sites
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 45 years old?
Source: NCT06424860, who can take part
Where in Canada
- Human Nutrition Research Unit - Li Ka Shing Health Research CenterEdmonton, CanadaContact: Donna Vine, PhDTaking people
- Mazankowski Alberta Heart InstituteEdmonton, CanadaContact: Donna Vine, PhDTaking people
- University of Alberta Hospital - Division of EndocrinologyEdmonton, CanadaContact: Beate Sydora, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Alberta
- Trial code
- NCT06424860
- Record updated
- 12 December 2025
- Original description
Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.Read full original descriptionShow less
Dietary Fish Oil and Metformin Intervention for Heart Health in PCOS
Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
Inclusion: diagnosis of PCOS; overweight-obese (BMI >25 kg/m2); elevated fasting plasma TG (>150 mg/dL); and/or apoB48-remnant cholesterol lipoproteins (>20 ug/ml); impaired insulin sensitivity (glucose 100-125 mg/dL and/or insulin >15 (uM/ml), and may be diagnosed with T2D (blood glucose >126 mg/dL).
Exclusion: -pregnancy, lactation.