Studies Epstein-Barr virus activity in people with Graves' disease
Observes whether Epstein-Barr virus reactivation is present in adults with Graves' disease.
Plain-language title generated from the registry record
Registry title: Graves' Disease Induced by Epstein-Barr Virus Lytic Reactivation
Key facts
- Where
- Nanjing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with newly diagnosed Graves' disease, or whose overactive thyroid came back after antithyroid drug treatment.
- Age
- 18 to 70 years
- Sex
- All sexes can join.
- Disease stage
- Newly diagnosed Graves' disease, or return of hyperthyroidism after treatment with antithyroid drugs.
- Earlier treatment
- People with a recurrence must have had antithyroid drug treatment before.
- Biomarker or test result
- The record lists blood tests (FT4, FT3, TSH, TPOAb, TGAb, TRAb) done for everyone. It sets no required result.
Main reasons for not taking part
- Subacute thyroiditis
- Hyperfunctioning thyroid nodules
- Iodine hyperthyroidism
- Drug-induced hyperthyroidism or other causes of hyperthyroidism
- Diabetes, infectious diseases, other chronic diseases or cancer
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06426758, who can take part
Where in China
- Nanjing First Hospital, Nanjing Medical UniversityNanjing, ChinaContact: Xiao-Ming Mao, MD.No longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Xiao-Ming Mao
- Trial code
- NCT06426758
- Record updated
- 23 May 2024
- Original description
Previous studies have proved that the lytic reactivation of latent Epstein-Barr virus (EBV) was significantly associated with the onset of Graves'disease (GD), however, the morbidity of GD and recurrence rate of hyperthyroidism after antithyroid drugs treatment due to lytic reactivation of EBV is not understood. We will recruit patients with newly diagnosed GD and recurrence of hyperthyroidism after antithyroid drugs treatment. In order to confirm lytic reactivation of EBV, the number of EBV DNA copies，mRNA and protein expression of immediate-early, early and late lytic EBV genes，EBV +TRAb+cells will be tested. The proportion of lytic reactivation of EBV in newly diagnosed GD and recurrence of hyperthyroidism was evaluated.Read full original descriptionShow less
The Morbidity of Graves' Disease and Recurrence Rate of Hyperthyroidism Due to Epstein-Barr Virus Lytic Reactivation
Previous studies have proved that the lytic reactivation of latent Epstein-Barr virus (EBV) was significantly associated with the onset of Graves'disease (GD), however, the morbidity of GD and recurrence rate of hyperthyroidism after antithyroid drugs treatment due to lytic reactivation of EBV is not understood. We will recruit patients with newly diagnosed GD and recurrence of hyperthyroidism after antithyroid drugs treatment. In order to confirm lytic reactivation of EBV, the number of EBV DNA copies，mRNA and protein expression of immediate-early, early and late lytic EBV genes，EBV +TRAb+cells will be tested. The proportion of lytic reactivation of EBV in newly diagnosed GD and recurrence of hyperthyroidism was evaluated.
Inclusion: The clinical evaluation included patient history, physical examination, and thyroid ultrasonography. Laboratory and diagnostic testing included determination of serum levels of free thyroxine (FT4), T3 ( FT3), thyrotropin (TSH), TPOAb, TGAb, and serum levels of thyrotropin receptor antibody (TRAb).
Exclusion: Patients with subacute thyroiditis, hyperfunctioning thyroid nodules, iodine hyperthyroidism, drug-induced hyperthyroidism, or other causes of hyperthyroidism were also excluded. The exclusion criteria for both patients with GD included diabetes, infectious diseases, other chronic diseases, and cancer.