Care bundle tested for brain bleeds caused by spontaneous intracerebral hemorrhage
Tests a structured care bundle against standard care in adults with brain bleeding.
Plain-language title generated from the registry record
Registry title: International Care Bundle Evaluation in Cerebral Hemorrhage Research
Key facts
- Where
- Greater Sudbury, Hamilton, and Ottawa, CanadaSee the 3 sites
- Phase
- Phase 4
Where in Canada
- Health Sciences North/Health Sciences North Research InstituteGreater Sudbury, CanadaTaking people
- Hamilton General HospitalHamilton, CanadaTaking people
- Ottawa Hospital Research InstituteOttawa, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Region Skane
- Trial code
- NCT06429332
- Record updated
- 22 May 2026
- Original description
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality. Approximately half of all patients with ICH have a decreased level of consciousness at hospital admission. Despite this, intensive care and neurosurgical interventions are uncommon. A study conducted in low- and middle-income countries has demonstrated a beneficial effect of a treatment package consisting of early intensive blood pressure lowering, as well as the treatment of pyrexia and elevated blood glucose levels. The I-CATCHER team is now planning to conduct a similar study in Sweden and Australia, as well as in other high-income countries. The study has a clear focus on implementation, aiming to improve treatment and prognosis for patients with ICH within a few years. The purpose of I-CATCHER is to investigate whether a structured treatment package (Care Bundle) improves 3-month prognosis in patients with spontaneous ICH compared to standard care.Read full original descriptionShow less
International Care Bundle Evaluation in Cerebral Hemorrhage Research - a Batched Parallel Cluster-randomized Trial With a Baseline Period
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality. Approximately half of all patients with ICH have a decreased level of consciousness at hospital admission. Despite this, intensive care and neurosurgical interventions are uncommon. A study conducted in low- and middle-income countries has demonstrated a beneficial effect of a treatment package consisting of early intensive blood pressure lowering, as well as the treatment of pyrexia and elevated blood glucose levels. The I-CATCHER team is now planning to conduct a similar study in Sweden and Australia, as well as in other high-income countries. The study has a clear focus on implementation, aiming to improve treatment and prognosis for patients with ICH within a few years. The purpose of I-CATCHER is to investigate whether a structured treatment package (Care Bundle) improves 3-month prognosis in patients with spontaneous ICH compared to standard care.
Inclusion: Adults (age ≥18 years); Non-contrast computerized tomography (NCCT) imaging-verified diagnosis of spontaneous intracerebral haemorrhage; ≤24 hours from symptom onset or presumed symptom onset (last seen well).
Exclusion: Previous care limitation; End-stage comorbidity with short life-expectancy (<6 m; e.g. terminal cancer); ICH caused by brain tumor or cerebral venous thrombosis; Clinical signs of brain herniation at first presentation (unresponsive patient with bilaterally fixed, maximally dilated pupils); Pregnant women beyond 22 weeks gestation may only be included after thorough discussion with an obstetrician to determine risks vs benefit.