Tests MRI and CT-guided high-dose radiation for abdominopelvic sarcomas
Tests targeted high-dose radiation before surgery in people with abdominopelvic sarcoma.
Plain-language title generated from the registry record
Registry title: Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)
Key facts
- Where
- Los Angeles, United StatesSee the site
- Phase
- Phase 2
Where in United States
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jonsson Comprehensive Cancer Center
- Trial code
- NCT06436612
- Record updated
- 5 June 2026
- Original description
Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation dose is administered to the cancerous tumor, not the vital body organs.Read full original descriptionShow less
Phase II Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)
Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation dose is administered to the cancerous tumor, not the vital body organs.
Potential participants with a sarcoma diagnosis will be referred to Radiation Oncology during this study. If the participant is interested in participating in this study, s/he receives radiation treatment daily for 5 consecutive days except for weekends and holidays. Within 12 weeks of completing the radiation therapy, the participant will have the primary tumor surgically removed. The radiation oncology team will follow the patients for 5 years after completing radiation therapy.
Inclusion: Histologically confirmed sarcoma; Primary or recurrent disease involving the abdomen or pelvis; Resectable primary lesion; Age ≥ 12 years old; Karnofsky performance status (KPS) ≥ 70 or Eastern Cooperative Oncology Group (ECOG) 0-2; If a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented.
Exclusion: History of prior irradiation to the area targeted for treatment; Active treatment of a separate malignancy.