Studying Genetic Changes in Fat Tissue Near Retroperitoneal Liposarcoma
Collects fat samples during surgery to study genetic changes linked to liposarcoma recurrence in adults.
Plain-language title generated from the registry record
Registry title: Genomic Risk in Retroperitoneal Sarcoma
Key facts
- Where
- Philadelphia, United StatesSee the site
Where in United States
- Fox Chase Cancer CenterPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fox Chase Cancer Center
- Trial code
- NCT06436846
- Record updated
- 31 May 2024
- Original description
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.Read full original descriptionShow less
Characterization of the Genomic Risk Underlying Retroperitoneal Liposarcoma
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.
Inclusion: Adult patients (age ≥18 years); Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection; Will be undergoing surgical resection for treatment of primary or recurrent disease; Have provided informed consent to participate in this study.
Exclusion: Prior surgical anatomy which makes sampling of remote areas of the retroperitoneum technically impossible or clinically undesirable for safety reasons.