Studying taste responses in Parkinson's disease and Lewy body disease
Compares brain taste responses in adults with early Parkinson's, Lewy body disease, and healthy volunteers.
Plain-language title generated from the registry record
Registry title: Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
Key facts
- Where
- Dijon, FranceSee the site
Where in France
- Chu Dijon BourgogneDijon, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Universitaire Dijon
- Trial code
- NCT06439355
- Record updated
- 7 October 2026
- Original description
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants:Read full original descriptionShow less
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants:
* healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease.
To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data.
This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.
Inclusion: Healthy volunteers:; Person who has given written consent; Adult; Enrolled in the national register of healthy volunteers; Fasting > 2 hours before PEG measurement; Body Mass Index (BMI) < 30 kg/m²; No cognitive complaints and normal neurological assessment; Patients with idiopathic Parkinson's disease:; Person who has given written consent; Adult; Fasting > 2 hours before PEG measurement; Body Mass Index (BMI) < 30 kg/m²; Diagnostic criteria for established or probable IPD; Patients with Lewy body disease:; Person who has given written consent; Adult; Fasting > 2 hours prior to PEG measurement; Body Mass Index (BMI) < 30 kg/m²; Diagnostic criteria for probable or possible LBD.
Exclusion: Known infection with COVID-19 in the 6 months prior to inclusion; Taking medication (in progress at the time of the study) that interferes with gustation; Non-affiliated to national health insurance; Person under legal protection (curatorship, guardianship); Person subject to a court order; Pregnant, parturient or breast-feeding women; Major unable to give consent; MMSE score < 15 and/or MoCA < 10; Active smoker (> 4 cigarettes per day on a regular basis); Subject with pacemaker (contraindication for bioelectrical impedancemetry); Diabetic (type 1 or type 2).