Tests high intensity stationary cycling and genetics in people with Parkinson disease
Studies how stationary cycling and genetics relate to Parkinson disease in adults.
Plain-language title generated from the registry record
Registry title: Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
Key facts
- Where
- Cleveland, United StatesSee the site
Where in United States
- The Cleveland ClinicCleveland, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jay Alberts
- Trial code
- NCT06442033
- Record updated
- 26 October 2026
- Original description
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.Read full original descriptionShow less
Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.
Inclusion: Adult with a diagnosis of PD by a physician or physician extender; Hoehn and Yahr stage I-III; Demonstrate the ability to safely mount and dismount a stationary cycle; Reliable transportation to the community exercise facility; Smartphone device for activity data monitoring; On a stable dose of anti-parkinsonian medication.
Exclusion: Participation in disease modifying PD-related clinical trial or study; Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent; A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in a cycling intervention f) Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) g) Current cardiac arrhythmia; Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation; Those who choose not to obtain physician clearance will not be eligible for participation; Implanted deep brain stimulation electrodes or focused ultrasound for PD management.