Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis
Key facts
- Where
- Girona, SpainSee the site
- Phase
- Phase 3
Where in Spain
- University Hospital of Girona Dr. Josep TruetaGirona, SpainContact: Montse Vendrell, PhD MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
- Trial code
- NCT06443658
- Record updated
- 3 July 2024
- Original description
Bronchiectasis is a chronic bronchial disease in which the usual capacity to remove secretions does not function correctly, causing mucus retention that leads to chronic infection. As with all infections, the use of antibiotics and puss removal are essential treatment elements. Physiotherapeutic techniques are used to assist in the removal of secretions, although these are time-consuming practices that need to be much better studied and which patients often do not continue practicing diligently. A physiotherapeutic technique called (Slow prolonged expiration in lateral decubitus) ELTGOL has been shown to be somewhat effective but as the mucus is viscous in this disorder, it can be difficult to get it to move. It is thought that saline solution inhalations may reduce mucus viscosity and could help to ease expectoration, facilitating the removal of the mucus by the physiotherapeutic technique. This project aims to test this hypothesis, which if true could represent an advance in the treatment of this severely debilitating disease.Read full original descriptionShow less
Benefits of Inhalation of Hypertonic Saline Solution Prior to ELTGOL Physiotherapy in Bronchiectasis
Bronchiectasis is a chronic bronchial disease in which the usual capacity to remove secretions does not function correctly, causing mucus retention that leads to chronic infection. As with all infections, the use of antibiotics and puss removal are essential treatment elements. Physiotherapeutic techniques are used to assist in the removal of secretions, although these are time-consuming practices that need to be much better studied and which patients often do not continue practicing diligently. A physiotherapeutic technique called (Slow prolonged expiration in lateral decubitus) ELTGOL has been shown to be somewhat effective but as the mucus is viscous in this disorder, it can be difficult to get it to move. It is thought that saline solution inhalations may reduce mucus viscosity and could help to ease expectoration, facilitating the removal of the mucus by the physiotherapeutic technique. This project aims to test this hypothesis, which if true could represent an advance in the treatment of this severely debilitating disease.
Inclusion: Adult patients with bronchiectasis confirmed by high resolution computed tomography; No exacerbations in the previous month; Chronic mucopurulent and purulent sputum; ≥10ml daily expectoration; At least one exacerbation in the previous year; (Forced expiratory volume the 1st second) FEV1 ≥30% after bronchodilation; Sign the informed consent.
Exclusion: Following mucoactive treatment in the previous month; Practicing pulmonary rehabilitation in the previous 6 months; Change of treatment the previous month; Current smokers or a smoking history of ≥20 p-y; Asthma, allergic bronchopulmonary aspergillosis or Cystic Fibrosis; Uncontrolled hypertension; Pregnant or lactating women; Inability to perform ELTGOL, spirometry or to attend visits.