CompletedNo phase
Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer
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Trial details
- Who runs it
- University Hospital, Bordeaux
- Trial code
- NCT06444477
- Record updated
- 26 January 2026
- Original description
The association between hematologic malignancies and ITP is well described, but this link is much less clear with solid cancers. In cases of ITP associated with cancers, specific cancer treatment can lead to remission or even cure of ITP. Thus, our hypothesis was that chronic expression of GPIIB by tumor cells could have initiated an autoimmune loop against GPIIB, leading to the onset and perpetuation of ITP.Read full original descriptionShow less
The association between hematologic malignancies and ITP is well described, but this link is much less clear with solid cancers. In cases of ITP associated with cancers, specific cancer treatment can lead to remission or even cure of ITP. Thus, our hypothesis was that chronic expression of GPIIB by tumor cells could have initiated an autoimmune loop against GPIIB, leading to the onset and perpetuation of ITP.
Inclusion: Adult patients with a definite diagnosis of both ITP and cancer; Synchronous diagnosis of ITP and cancer; Onset of ITP occurring 6 months before or after the diagnosis of cancer.
Exclusion: None.