Studies tiny particles from fat tissue in people with obesity
Compares fat-derived particles and insulin sensitivity in lean and obese adults.
Plain-language title generated from the registry record
Registry title: Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Key facts
- Where
- Genk, BelgiumSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06444646, who can take part
Where in Belgium
- Ziekenhuis Oost-LimburgGenk, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hasselt University
- Trial code
- NCT06444646
- Record updated
- 15 September 2025
- Original description
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.Read full original descriptionShow less
The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
Individuals with obesity - Inclusion Criteria:; Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery; Final male/female ratio of this study is 1:1; Minimal knowledge of Dutch to read and understand the informed consent; Individuals with obesity - Exclusion Criteria:; Smoking and/or drug abuse; Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator); Lung and/or kidney diseases; Brain and/or nerve diseases; Malignant diseases (e.g. cancer); Individuals without obesity (lean) - inclusion criteria; Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery; Female only; Minimal knowledge of Dutch to read and understand the informed consent; Individuals without obesity (lean) - exclusion criteria; Smoking and/or drug abuse; Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator); Lung and/or kidney diseases; Brain and/or nerve diseases; Endocrine diseases like type 2 diabetes; Malignant diseases (e.g. cancer).