Studies tiny particles from fat tissue in people with obesity
Compares fat-derived particles and insulin sensitivity in lean and obese adults.
Plain-language title generated from the registry record
Registry title: Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Key facts
- Where
- Genk, BelgiumSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for Caucasian adults with obesity who are about to have their first weight-loss surgery, and lean women who are about to have abdominal surgery.
- Age
- 18 to 65 years
- Sex
- All sexes can join. The lean group is women only. The study aims for equal numbers of men and women overall.
- Disease stage
- Obesity group: body mass index (BMI) of at least 35 kg/m^2. Lean group: BMI between 18 and 24.9 kg/m^2.
- Earlier treatment
- Obesity group: scheduled for their first bariatric surgery. Lean group: scheduled for abdominal surgery.
Main reasons for not taking part
- Smoking and/or drug abuse
- Heart or blood vessel disease, including a pacemaker or defibrillator
- Lung and/or kidney disease
- Brain and/or nerve disease
- Cancer; lean group also cannot have endocrine diseases like type 2 diabetes
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06444646, who can take part
Where in Belgium
- Ziekenhuis Oost-LimburgGenk, BelgiumContact: Lisa Mennens, MScTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Hasselt University
- Trial code
- NCT06444646
- Record updated
- 15 September 2025
- Original description
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.Read full original descriptionShow less
The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
Individuals with obesity - Inclusion Criteria:; Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery; Final male/female ratio of this study is 1:1; Minimal knowledge of Dutch to read and understand the informed consent; Individuals with obesity - Exclusion Criteria:; Smoking and/or drug abuse; Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator); Lung and/or kidney diseases; Brain and/or nerve diseases; Malignant diseases (e.g. cancer); Individuals without obesity (lean) - inclusion criteria; Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery; Female only; Minimal knowledge of Dutch to read and understand the informed consent; Individuals without obesity (lean) - exclusion criteria; Smoking and/or drug abuse; Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator); Lung and/or kidney diseases; Brain and/or nerve diseases; Endocrine diseases like type 2 diabetes; Malignant diseases (e.g. cancer).