NCT06445673Enrolling by invitation
A Prospective Non-interventional Observational Study to Observe Long-term Treatment and Outcomes in Pulmonary Arterial Hypertension (PAH) Patients
A Prospective, Multicenter, International Non-interventional, Observational Cohort Study to Observe Long-term Treatment Patterns and Real-word Outcomes in PAH Group I Patients Previously Participating in TripleTRE - TripleTRE-NIS
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about the long-term development and outcomes of different treatment patterns of patients who initially participated in the TripleTRE study. The primary objective of this non-interventional follow-up study is to assess the long-term real-world clinical outcomes, including disease progression and survival rates, in patients who initially participated in and completed the randomized TripleTRE trial. Planned observation duration per patient is a minimum of 3 years.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 110 (estimated)
- First submitted
- 29 May 2024
- Start date
- Jul 2024
- Primary completion date
- Jun 2030
- Lead sponsor
- AOP Orphan Pharmaceuticals AG
- NCT number
- NCT06445673
What you commit to
- Study type: Observational
- Planned participants: 110
- From Jul 2024 to the primary completion date, Jun 2030
- 18 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who discontinued all medicinal PAH treatments (e.g. after successful lung transplantation)
- Patients who withdrew from the initial TripleTRE trial due to significant non-compliance with trial requirements (not adhering to therapy, not coming to hospital visits)
Other
- Lost to follow-up patients of TripleTRE study
Who the study is looking for
- 1\. Patients previously participating in the randomized TripleTRE trial who are able and willing to provide a signed informed consent for study participation in NIS
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ordensklinikum Linz Coordinator of this site? Confirm its status | Linz | Austria | Unknown status |
| Medical University Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Unknown status |
| Fakultni nemocnice Olomouc Coordinator of this site? Confirm its status | Olomouc | Czechia | Unknown status |
| Vseobecna fakultni nemocnice v Praze Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| DRK Kliniken Berlin Westend Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| University Hospital Carl Gustav Carus of Technical University Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| Universitätsmedizin Greifswald Coordinator of this site? Confirm its status | Greifswald | Germany | Unknown status |
| Hospital Clinic of Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hôpital Bicêtre-- Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hopitaux Universitaires de Strasbourg Coordinator of this site? Confirm its status | Strasbourg | France | Unknown status |
| Gottsegen National Cardiovascular lnstitute Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| Medical University of Szeged Coordinator of this site? Confirm its status | Szeged | Hungary | Unknown status |
| Sapienza University Of Rome Coordinator of this site? Confirm its status | Rome | Italy | Unknown status |
| John Paul II Hospital Krakow Coordinator of this site? Confirm its status | Krąków | Poland | Unknown status |
| Fryderyk Chopin Hospital in European Health Centre Otwock Coordinator of this site? Confirm its status | Otwock | Poland | Unknown status |
| Emergency Institute for Cardiovascular Diseases Prof. Dr. C.C.Iliescu Coordinator of this site? Confirm its status | Bucharest | Romania | Unknown status |
| Emergency Clinical County Hospital of Targu Mures Coordinator of this site? Confirm its status | Târgu Mureş | Romania | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.