Frontlight ResearchEarly access
Active, not recruitingPhase 2
Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder
Key facts
- Who runs it
- Yale University
- Where
- New Haven, United StatesSee the site
- Trial code
- Status
- Active, not recruiting
- Phase
- Phase 2
- People taking part
- 46 people enrolled
- Started
- 13 Mar 2025
- Expected to end
- 30 Mar 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- mindfulness-based Neurofeedback
- control Neurofeedback
- Record updated
- 19 October 2026
Who can take part
- Age
- 18 years to 60 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 20 criteriaShow less
Who can take part
- age 18-60,
- be able to provide written informed consent,
- meet criteria for BPD on semi-structured clinical interview,
- able to plan to keep any prescribed medications and psychotherapy constant during the study
- fluent in English
Who cannot take part
- newly prescribed medications in the past 8 weeks
- daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
- lifetime primary psychotic disorder
- developmental disorder (e.g. autism)
- history of learning disorder
- severe substance use disorder in the last 3 months
- history of major medical or neurologic disorder
- current DBT psychotherapy outside the study
- manic episode in the last one year
- active suicidal ideation with intent or plan in the past 3 months
- MRI contraindications, including pregnancy
- poor performance on reading task (WRAT > 11 errors)
- any scheduled daily benzodiazepines
- change in psychotherapy type or frequency in the past 12 weeks
- At the discretion of the study PI; Eligibility will be determined by study personnel
Where in United States
- Connecticut Mental Health CenterNew Haven, United States
About the trial
What the trial wants to find out
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
The 2 groups in the trial
- mindfulness-based NeurofeedbackTreatment being tested
Participants will participate in one session of mindfulness-based fMRI neurofeedback followed by 20 weeks of remote online weekly Dialectical Behavior Therapy skills group.
- control NeurofeedbackOther group
Participants will participate in one session of control fMRI neurofeedback followed by 20 weeks of remote online weekly Dialectical Behavior Therapy skills group.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)
- Publications
- A protocol for MIndfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD).PloS one, 2026
- A protocol for MIndfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD).medRxiv : the preprint server for health sciences, 2025
- Record updated
- 19 October 2026