Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer
Key facts
- Where
- Moscow, RussiaSee the site
Where in Russia
- Blokhin's Russian Cancer Research CenterMoscow, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Blokhin's Russian Cancer Research Center
- Trial code
- NCT06449989
- Record updated
- 5 October 2026
- Original description
GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.Read full original descriptionShow less
GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.
Inclusion: Men and women over 18 years of age; Histologically confirmed cancer of the colon or rectum; Histologically confirmed metastatic lesion of the brain; Neurosurgical resection for brain metastases of colorectal cancer; Presence of paired tumor samples (both primary tumor and intracranial material).
Exclusion: Missing one sample from a pair of tumor samples; Low quality or lack of tumor material for molecular genetic research.