Catheter Ablation of Haemodynamically Not-tolerated Electrical Storm in Structural Heart Disease
Key facts
- Who runs it
- Beijing Anzhen Hospital
- Where
- Beijing, Changsha, Kunming, and Nanjing, ChinaSee the 4 sites
- Trial code
- Status
- Not yet recruiting
- People taking part
- 96 people, planned
- Started
- 1 Jul 2024
- Expected to end
- 30 Jun 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Catheter ablation
- Stepped-care strategies
- Record updated
- 12 June 2024
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Patients aged 18 to 80 years
- Having structural heart disease, including ischemic cardiomyopathy and nonischemic cardiomyopathy
- Haemodynamically not-tolerated, defined as persistent hypotension (systolic blood pressure <90 mmHg and mean arterial pressure 30 mmHg lower than baseline or <70 mmHg, with associated signs of end-organ hypoperfusion)
- Electrical storm, defined as >3 VT episodes within 24 hours
Who cannot take part
- Ventricular thrombosis diagnosed by echocardiography and/or cardiac magnetic resonance
- Acute ST-segment-elevation myocardial infarction within 60 days
- Cardiac surgery within 60 days
- Unstable angina
- Reversible causes of ventricular tachycardia or cardiomyopathy
- Pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in China
- Beijing Anzhen Hospital, Capital Medical UniversityBeijing, ChinaContact: Mengmeng LiNo longer taking part
- Second Xiangya Hospital, Central South UniversityChangsha, ChinaContact: Qiming Liu, MDNo longer taking part
- The Affiliated YanAn Hospital of KunMing Medical UniversityKunming, ChinaContact: Shaolong Li, MDNo longer taking part
- The First Affiliated Hospital of Nanjing Medical UniversityNanjing, ChinaContact: Jiangang Zou, MDNo longer taking part
About the trial
What the trial wants to find out
This is a multi-center, parallel-group, randomized, open-label trial evaluating the clinical outcome and efficacy of emergency catheter ablation versus conventional stepped-care strategies in patients with haemodynamically not-tolerated ventricular tachycardia (VT).
The 2 groups in the trial
- Catheter ablationTreatment being tested
Patients randomized to the emergency catheter ablation arm will first undergo catheter ablation. Vasopressors, antiarrhythmic drugs, and hemodynamic mechanical support devices will be adopted as needed. All patients will be advised for ICD implantation before discharge.
- Stepped-care strategiesExisting treatment, for comparison
Patients randomized to the stepped-care strategies arm will undergo a stepwise progressive procedure, with anti-arrhythmic drugs, sedation and anesthesia, and hemodynamic mechanical support devices, that is, the next treatment is only started when the previous sequence of treatment is ineffective, and catheter ablation is only used as the final rescue treatment. All patients will be advised for ICD implantation before discharge.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT06455020, who can take part
- Record updated
- 12 June 2024