Brain Imaging Study of Minor Strokes Caused by Large Artery Blockage
Uses a special brain scan to track chemical changes in adults with a minor stroke.
Plain-language title generated from the registry record
Registry title: MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT06457217, who can take part
Where in China
- Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shanghai 6th People's Hospital
- Trial code
- NCT06457217
- Record updated
- 16 October 2024
- Original description
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are:Read full original descriptionShow less
Magnetic Resonance Spectroscopic Imaging Evaluation for Understanding Acute Minor Stroke With Large Vessel Occlusion Evolution Study
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are:
1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.
Inclusion: Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery; Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)<6); Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital; Time from symptom onset or last known normal to enrollment is less than 24 hours; Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent.
Exclusion: Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism; Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases; Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders); A pre-incident mRS ≥ 1 point before onset; Intolerance or non-cooperation with magnetic resonance examination; Pregnancy or lactation; Life expectancy is less than 3 months.