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Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement

Key facts

Who runs it
Istituto Ortopedico Rizzoli
Where
Italy1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
150 people, planned
Started
12 Jan 2023
Expected to end
Oct 2027
Type of study
Observational, 2 groups
Treatments tested
  • High tibial osteotomy
Record updated
29 January 2026

Who can take part

Age
18 years to 70 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Patients undergoing corrective knee osteotomy and any associated procedures such as meniscal repair/resection/replacement, ligament reconstruction, chondral treatment, or regenerative infiltrative treatment
  • Patients aged between 18 and 70 years at the time of surgical intervention
  • Patients with isolated compartmental osteoarthritis
  • Patients with a varus or valgus knee alignment defect of at least 3° compared to mechanical neutrality

Who cannot take part

  • Women of childbearing age who cannot exclude pregnancy
  • Patients with advanced multicompartimental osteoarthritis
  • Patients who are no longer reachable
  • Patients unable to give informed consent or patients unwilling to sign the informed consent form

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 70 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The present study aims to evaluate the long-term and medium-term outcomes of different knee osteotomy techniques in the treatment of knee osteoarthritis in patients with lower limb malalignment. This evaluation is necessary in the current context of research on the treatment and prevention of knee osteoarthritis through treatments that do not involve or allow for the postponement of prosthetic replacement. Among the biological treatments performed in orthopedic clinical practice, osteotomy is one of the most promising. However, further long-term evaluations are needed to more clearly determine the indications and potential of this type of intervention, considering the various surgical procedures described for performing it.

The 2 groups in the trial

  • Closing wedge

    Patients undergoing closing wedge high tibial osteotomy in knee ostheoarthritis and lower limb malalignement

    Treatment: High tibial osteotomy

  • Opening wedge

    Patients undergoing opening wedge high tibial osteotomy in knee ostheoarthritis and lower limb malalignement

    Treatment: High tibial osteotomy

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Long-term Clinical and Radiographic Outcomes of Different Knee Osteotomy Techniques for the Treatment of Compartmental Knee Osteoarthritis With Lower Limb Malalignment.
Fit questions
Built from NCT06462625, who can take part
Record updated
29 January 2026