Tests a brain stimulation device for thinking problems in schizophrenia
Tests high-frequency brain stimulation against a sham in adults with schizophrenia.
Plain-language title generated from the registry record
Registry title: The Hi-tACS on Cognitive Function in Patients With Schizophrenia
Key facts
- Where
- Hanzhou and Quzhou, ChinaSee the 2 sites
Where in China
- Sir Run Run Shaw HospitalHanzhou, ChinaTaking people
- Quzhou Third HospitalQuzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sir Run Run Shaw Hospital
- Trial code
- NCT06470516
- Record updated
- 2 March 2026
- Original description
This study is a double-blind, randomized, controlled intervention study aimed at exploring whether high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive impairment in patients with schizophrenia.Read full original descriptionShow less
The Impact of High-frequency Transcranial Alternating Current Stimulation (Hi-tACS) on Cognitive Function in Patients With Schizophrenia
This study is a double-blind, randomized, controlled intervention study aimed at exploring whether high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive impairment in patients with schizophrenia.
Inclusion: Meets the diagnostic criteria for schizophrenia according to DSM-5; Age ≥ 18 years old; Right-handed; Willing to participate in this study and sign an informed consent form. If the participant is unable to read and sign the informed consent form due to lack of capacity, a legal guardian must act as a proxy during the informed consent process and sign the form; Clinically stable, receiving antipsychotic medication treatment with a stable dose for 4 weeks without any changes; Montreal Cognitive Assessment score ≥ 10 points.
Exclusion: Those who have received MECT or TMS treatment within 1 month before enrollment; Implants of metal or electronic devices (such as pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.); Participation in any other clinical trials within 1 month prior to baseline; Psychotic disorders caused by split affective disorder, bipolar disorder, intellectual disability, anxiety spectrum disorders, drugs, alcohol, and other psychoactive substances according to DSM-V diagnostic criteria; Those with severe or unstable organic diseases, with a history of brain tumors or epilepsy; Skin integrity at the electrode placement site is compromised. Allergy to electrode gel or adhesive; The investigator believes that there are inappropriate conditions for participating in this study; Pregnant and lactating women.