Stenting versus continued clot removal for stroke from artery narrowing
Compares early stenting with continued clot removal in adults with stroke from artery narrowing.
Plain-language title generated from the registry record
Registry title: IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
Key facts
- Where
- Basel, SwitzerlandSee the site
Where in Switzerland
- University Hospital Basel, Department of Interventional and Diagnostical NeuroradiologyBasel, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Basel, Switzerland
- Trial code
- NCT06472336
- Record updated
- 17 December 2025
- Original description
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis.Read full original descriptionShow less
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting - a Pragmatic, International, Multicentre, Randomized Trial
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis.
Inclusion: A relevant clinical deficit defined as a National Institute of Health Stoke Scale (NIHSS) Score of ≥ 6 points for anterior circulation stroke and a NIHSS Score of ≥ 10 for posterior circulation stroke; Anticipated randomization within 24 hours of last seen well (LSW); Occlusion of the Internal Carotid Artery, the M1 segment, the proximal/dominant M2 segment of the Middle Cerebral Artery, the Basilar Artery or the V4 segment of the Vertebral Artery; Absence of recanalization (thrombolysis in myocardial infarction score of 0 or 1) after up to three endovascular treatment passes; High probability of underlying intracranial atherosclerotic disease based on the assessment of the treating physician; Age ≥ 18 years; Occluded artery amendable to stenting by judgement of the treating physician; Absence of a large infarct core defined as (posterior circulation) Alberta Stroke Program Early CT Score of 6 or above; Informed Consent as documented by signature or fulfilling the criteria for emergency consent procedures.
Exclusion: Evidence of an ongoing pregnancy prior to randomization; Evidence of vessel recanalization prior to randomisation; Acute intracranial haemorrhage; Pre-stroke modified Rankin Scale score of 3 or above; Known, severe comorbidities, which will likely prevent improvement or follow-up (cancer, alcohol/drug abuse or dementia); Known clotting disease or suspicion of underlying disease which might lead to a hyper coagulant state; In-hospital Stroke; Known contraindications for anti-platelet therapy; Known (serious) sensitivity to radiographic contrast agents, nickel, titanium metals or their alloys; Foreseeable difficulties in follow-up due to geographic reasons (e.g., patients living abroad); Radiological confirmed evidence of mass effect or intracranial tumour (except small meningioma); Radiological confirmed evidence of cerebral vasculitis; Participation in another interventional trial which could confound the primary endpoint.