Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)
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- Who runs it
- General Hospital of Shenyang Military Region
- Trial code
- NCT06483737
- Record updated
- 26 August 2025
- Original description
Hepatic encephalopathy (HE), a severe complication of decompensated cirrhosis, is characterized as neurocognitive dysfunction. Emerging evidence suggests the potential role of human albumin infusion for the treatment of HE, but its optimal dosage remains undefined. Therefore, the investigators planned a randomized controlled trial (RCT) to compare the efficacy of human albumin infusion at different dosages in in patients with liver cirrhosis and overt HE.Read full original descriptionShow less
Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE): an Invesitgator-initiated, Open-label, Multicenter, Randomized Controlled Trial
Hepatic encephalopathy (HE), a severe complication of decompensated cirrhosis, is characterized as neurocognitive dysfunction. Emerging evidence suggests the potential role of human albumin infusion for the treatment of HE, but its optimal dosage remains undefined. Therefore, the investigators planned a randomized controlled trial (RCT) to compare the efficacy of human albumin infusion at different dosages in in patients with liver cirrhosis and overt HE.
Inclusion: A definite diagnosis of liver cirrhosis and overt HE; A serum albumin level of 23-30g/L; Age ≥18 years old; Sign the informed consent.
Exclusion: A history of transjugular intrahepatic portosystemic shunt; A diagnosis of acute liver failure; Severe heart and/or lung diseases; Psychiatric or nervous diseases; Contraindications to human albumin infusion; Pregnant or lactating.