Tests a high-fiber diet in adults with rheumatoid arthritis
Tests whether more dietary fiber, with psyllium husk, helps adults with rheumatoid arthritis.
Plain-language title generated from the registry record
Registry title: Impact of a High-fiber Diet on the Microbiome and Disease Activity in Patients With Rheumatoid Arthritis
Key facts
- Where
- Würzburg, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT06492200, who can take part
Where in Germany
- University WürzburgWürzburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wuerzburg University Hospital
- Trial code
- NCT06492200
- Record updated
- 9 July 2024
- Original description
The goal of this clinical trial is to learn if increasing dietary fiber can improve the gut microbiome and reduce disease activity in adults with rheumatoid arthritis (RA). The main questions it aims to answer are:Read full original descriptionShow less
Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis
The goal of this clinical trial is to learn if increasing dietary fiber can improve the gut microbiome and reduce disease activity in adults with rheumatoid arthritis (RA). The main questions it aims to answer are:
* Can a higher fiber diet improve gut bacteria and produce beneficial short-chain fatty acids (SCFAs)? * Does a higher fiber diet reduce RA symptoms and help with weight loss?
Researchers will compare two groups: one group will receive dietary counseling and take 10 grams of psyllium husk daily, while the other group will continue their usual diet.
Participants will:
* Complete dietary questionnaires at the start, 6 months, and 12 months. * Provide stool samples for gut bacteria and SCFA analysis. * Have their RA activity and body weight monitored regularly. * Receive regular phone calls to support the dietary changes.
The study will involve adults with diagnosed RA who can provide informed consent and meet other inclusion criteria.
Inclusion: Patients over 18 years old; Diagnosis of Rheumatoid Arthritis according to the ACR criteria of 2010; The patient can understand the scope of the study and consents in writing to participate.
Exclusion: Use of ground psyllium husks four weeks prior to study inclusion; Chronic inflammatory bowel disease; History of mechanical ileus; Age under 18; Lack of consent capability; Insufficient knowledge of the German language; Liver cirrhosis; Patients with altered gastrointestinal passage (e.g., stoma patients); Use of antibiotics within the past three months.