Taking people in United StatesPhase 3

Durvalumab Versus Observation After Surgery for Early Lung Cancer With No Remaining Cancer Cells

Tests durvalumab after surgery in adults with early-stage non-small cell lung cancer.

Plain-language title generated from the registry record
Registry title: Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Key facts

Where: ‘Aiea, ‘Ewa Beach, Aberdeen, Albuquerque, Allentown, Ames, Anaconda, Ankeny, Ann Arbor, Antigo, Ashland, Atlanta, Augusta, Avon, Ballwin, Baltimore, Battle Creek, Bemidji, Bethlehem, Beverly, Beverly Hills, Billings, Bismarck, Boiling Springs, Boise, Boone, Bozeman, Brainerd, Brighton, Bryn Mawr, Buffalo, Burlington, Canton, Carmel, Carroll, Cary, Cedar Rapids, Centerville, Chelsea, Chicago, Clearwater, Clinton Township, Clive, Coeur d'Alene, Collierville, Columbus, Coon Rapids, Cumberland, Dayton, Decatur, Deer River, DeKalb, Denver, Des Moines, Detroit, Dublin, Duluth, Durham, Easley, East China Township, East Stroudsburg, Eau Claire, Edina, Edmonds, Erie, Escanaba, Fargo, Flint, Fort Dodge, Franklin, Fredericksburg, Fremont, Fresno, Fruitland, Gaffney, Geneva, Georgetown, Glenview, Gloucester, Grand Junction, Grand Rapids, Grayslake, Great Falls, Green Bay, Greensburg, Greenville, Greer, Grenada, Grosse Pointe Woods, Harrisburg, Hartford, Hays, Hazleton, Hibbing, Honolulu, Hood River, Huntington, Huntley, Indianapolis, Issaquah, Jackson, Jefferson, Johns Creek, Jonesboro, Kalamazoo, Kalispell, Kansas City, La Crosse, La Jolla, Lafayette, Lake Forest, Lansing, Lawrence, Livonia, Loma Linda, Lone Tree, Los Angeles, Lynchburg, Macomb, Manchester, Marshalltown, Marshfield, Maywood, Mechanicsburg, Medford, Media, Memphis, Meriden, Meridian, Miami, Millville, Minneapolis, Missoula, Modesto, Monroeville, Mukwonago, Murrells Inlet, Muskegon, Nampa, New Albany, New Britain, New Orleans, Newark, Newberg, Niles, Norton Shores, Novi, Oak Brook, Oakland, Oconomowoc, Oconto Falls, Oklahoma City, Olathe, Oregon City, Orland Park, Oxford, Paoli, Peabody, Philadelphia, Pinehurst, Pittsburgh, Plant City, Pontiac, Portland, Post Falls, Raleigh, Reed City, Rehoboth Beach, Rhinelander, Richmond, Roseville, Royal Oak, Sacramento, Saint Joseph, Saint Louis Park, Saint Paul, Salina, San Francisco, San Jose, San Leandro, San Rafael, Sandpoint, Sandstone, Santa Clara, Santa Rosa, Scarborough, Seattle, Seneca, Sheboygan, Sioux Falls, South Hill, South Portland, South San Francisco, Southfield, Southhaven, Spartanburg, Springfield, St Louis, St. Petersburg, Stevens Point, Sturgeon Bay, Tampa, The Bronx, Topeka, Torrance, Traverse City, Troy, Union, Vallejo, Virginia, Walnut Creek, Warren, Warrenville, Waukee, Waukesha, Wausau, West Reading, Weston, Winter Haven, Wisconsin Rapids, Worcester, Wynnewood, Wyoming, and Ypsilanti, United StatesSee the 284 sites
Phase: Phase 3

Where in United States

Hawaii Cancer Care - Westridge‘Aiea, United StatesTaking people
The Queen's Medical Center - West Oahu‘Ewa Beach, United StatesTaking people
UM Upper Chesapeake Hematology and Oncology - AberdeenAberdeen, United StatesTaking people
University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
Mary Greeley Medical CenterAmes, United StatesTaking people
McFarland Clinic - AmesAmes, United StatesTaking people
Community Hospital of AnacondaAnaconda, United StatesTaking people
UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
Aspirus Cancer Care-Antigo-Volm Cancer CenterAntigo, United StatesTaking people
Duluth Clinic AshlandAshland, United StatesTaking people
Emory Saint Joseph's HospitalAtlanta, United StatesTaking people
Emory University Hospital MidtownAtlanta, United StatesTaking people
Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
Harold Alfond Center for Cancer CareAugusta, United StatesTaking people
Hartford HealthCare - AvonAvon, United StatesTaking people
IU Health West HospitalAvon, United StatesTaking people
Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesTaking people
Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
Bronson Battle CreekBattle Creek, United StatesTaking people
Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
Beverly HospitalBeverly, United StatesTaking people
Tower Cancer Research FoundationBeverly Hills, United StatesTaking people
Billings Clinic Cancer CenterBillings, United StatesTaking people
Saint Vincent Frontier Cancer CenterBillings, United StatesTaking people
Sanford Bismarck Medical CenterBismarck, United StatesTaking people
Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesTaking people
Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
McFarland Clinic - BooneBoone, United StatesNo longer taking part
Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
University of Michigan - Brighton Center for Specialty CareBrighton, United StatesTaking people
Bryn Mawr HospitalBryn Mawr, United StatesTaking people
Roswell Park Cancer InstituteBuffalo, United StatesNo longer taking part
Lahey ClinicBurlington, United StatesTaking people
Aultman Health FoundationCanton, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
IU Health North HospitalCarmel, United StatesTaking people
Saint Anthony Regional HospitalCarroll, United StatesTaking people
Duke Cancer Center CaryCary, United StatesNo longer taking part
Mercy HospitalCedar Rapids, United StatesTaking people
Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
Miami Valley Hospital SouthCenterville, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
Northwestern UniversityChicago, United StatesTaking people
Morton Plant HospitalClearwater, United StatesTaking people
Henry Ford Macomb Hospital-Clinton TownshipClinton Township, United StatesTaking people
UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, United StatesTaking people
Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
Mercy HospitalCoon Rapids, United StatesTaking people
UPMC Western MarylandCumberland, United StatesTaking people
Miami Valley HospitalDayton, United StatesTaking people
Miami Valley Hospital NorthDayton, United StatesTaking people
Emory Decatur HospitalDecatur, United StatesTaking people
Essentia Health - Deer River ClinicDeer River, United StatesTaking people
Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
Kaiser Permanente-FranklinDenver, United StatesTaking people
Broadlawns Medical CenterDes Moines, United StatesTaking people
Iowa Methodist Medical CenterDes Moines, United StatesTaking people
Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
Henry Ford Health Saint John HospitalDetroit, United StatesTaking people
Henry Ford HospitalDetroit, United StatesTaking people
Kaiser Permanente DublinDublin, United StatesTaking people
Essentia Health Cancer CenterDuluth, United StatesTaking people
Duke University Medical CenterDurham, United StatesTaking people
Durham VA Medical CenterDurham, United StatesTaking people
Prisma Health Cancer Institute - EasleyEasley, United StatesTaking people
Henry Ford River District HospitalEast China Township, United StatesTaking people
Pocono Medical CenterEast Stroudsburg, United StatesTaking people
Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
Fairview Southdale HospitalEdina, United StatesTaking people
Minnesota Oncology - EdinaEdina, United StatesTaking people
Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
UPMC Hillman Cancer Center ErieErie, United StatesTaking people
OSF Saint Francis Hospital and Medical GroupEscanaba, United StatesTaking people
Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
Sanford Broadway Medical CenterFargo, United StatesTaking people
Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
Cancer Hematology Centers - FlintFlint, United StatesTaking people
Genesys Hurley Cancer InstituteFlint, United StatesTaking people
Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesTaking people
UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, United StatesTaking people
Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesTaking people
Hematology Oncology Associates of Fredericksburg IncFredericksburg, United StatesTaking people
Kaiser Permanente-FremontFremont, United StatesTaking people
Kaiser Permanente Fresno Orchard PlazaFresno, United StatesTaking people
Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
Gibbs Cancer Center-GaffneyGaffney, United StatesTaking people
Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
Tidelands Georgetown Memorial HospitalGeorgetown, United StatesTaking people
Northwestern Medicine Glenview Outpatient CenterGlenview, United StatesTaking people
Addison Gilbert HospitalGloucester, United StatesTaking people
Saint Mary's Hospital and Regional Medical CenterGrand Junction, United StatesTaking people
Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
Northwestern Medicine Grayslake Outpatient CenterGrayslake, United StatesTaking people
Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesTaking people
Miami Valley Cancer Care and InfusionGreenville, United StatesTaking people
Prisma Health Cancer Institute - ButternutGreenville, United StatesTaking people
Prisma Health Cancer Institute - EastsideGreenville, United StatesTaking people
Prisma Health Cancer Institute - FarisGreenville, United StatesTaking people
Gibbs Cancer Center-PelhamGreer, United StatesTaking people
Prisma Health Cancer Institute - GreerGreer, United StatesTaking people
Baptist Cancer Center-GrenadaGrenada, United StatesTaking people
Henry Ford Saint John Hospital - AcademicGrosse Pointe Woods, United StatesTaking people
Henry Ford Saint John Hospital - BreastGrosse Pointe Woods, United StatesTaking people
Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, United StatesTaking people
UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesTaking people
Hartford HospitalHartford, United StatesTaking people
HaysMedHays, United StatesTaking people
Lehigh Valley Hospital-HazletonHazleton, United StatesTaking people
Essentia Health Hibbing ClinicHibbing, United StatesTaking people
Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, United StatesTaking people
Kaiser Permanente Moanalua Medical CenterHonolulu, United StatesTaking people
Queen's Cancer Cenrer - POB IHonolulu, United StatesTaking people
Queen's Cancer Center - KuakiniHonolulu, United StatesTaking people
Queen's Medical CenterHonolulu, United StatesTaking people
Providence Hood River Memorial HospitalHood River, United StatesTaking people
Edwards Comprehensive Cancer CenterHuntington, United StatesTaking people
Northwestern Medicine Huntley HospitalHuntley, United StatesTaking people
Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesTaking people
Sidney and Lois Eskenazi HospitalIndianapolis, United StatesTaking people
Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
University of Mississippi Medical CenterJackson, United StatesTaking people
McFarland Clinic - JeffersonJefferson, United StatesNo longer taking part
Emory Johns Creek HospitalJohns Creek, United StatesTaking people
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, United StatesTaking people
Bronson Methodist HospitalKalamazoo, United StatesTaking people
West Michigan Cancer CenterKalamazoo, United StatesTaking people
Logan Health Medical CenterKalispell, United StatesTaking people
University Health Truman Medical CenterKansas City, United StatesTaking people
Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
UC San Diego Moores Cancer CenterLa Jolla, United StatesTaking people
Kaiser Permanente-Rock CreekLafayette, United StatesTaking people
Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
Lawrence Memorial HospitalLawrence, United StatesTaking people
Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
Veterans Affairs Loma Linda Healthcare SystemLoma Linda, United StatesTaking people
Kaiser Permanente-Lone TreeLone Tree, United StatesTaking people
Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
Centra Alan B Pearson Regional Cancer CenterLynchburg, United StatesTaking people
Henry Ford Saint John Hospital - Macomb MedicalMacomb, United StatesTaking people
Henry Ford Warren Hospital - Breast MacombMacomb, United StatesTaking people
Hartford HealthCare - ManchesterManchester, United StatesTaking people
McFarland Clinic - MarshalltownMarshalltown, United StatesTaking people
Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
Loyola University Medical CenterMaywood, United StatesTaking people
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesTaking people
Aspirus Medford HospitalMedford, United StatesTaking people
Riddle Memorial HospitalMedia, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesTaking people
Midstate Medical CenterMeriden, United StatesTaking people
Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
Miami Cancer InstituteMiami, United StatesTaking people
Beebe South Coastal Health CampusMillville, United StatesTaking people
Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
Minneapolis VA Medical CenterMinneapolis, United StatesTaking people
Community Medical CenterMissoula, United StatesTaking people
Kaiser Permanente- Modesto MOB IIModesto, United StatesTaking people
UPMC Hillman Cancer Center - MonroevilleMonroeville, United StatesTaking people
ProHealth D N Greenwald CenterMukwonago, United StatesTaking people
MUSC Hematology-Oncology at Murrells InletMurrells Inlet, United StatesTaking people
Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, United StatesTaking people
The Hospital of Central ConnecticutNew Britain, United StatesTaking people
University Medical Center New OrleansNew Orleans, United StatesTaking people
Helen F Graham Cancer CenterNewark, United StatesTaking people
Medical Oncology Hematology Consultants PANewark, United StatesTaking people
Providence Newberg Medical CenterNewberg, United StatesTaking people
Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
Henry Ford Health Providence Novi HospitalNovi, United StatesTaking people
Northwestern Medicine Oak BrookOak Brook, United StatesTaking people
Kaiser Permanente-OaklandOakland, United StatesTaking people
ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesTaking people
Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, United StatesTaking people
University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
The University of Kansas Cancer Center - OlatheOlathe, United StatesTaking people
Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-OxfordOxford, United StatesTaking people
Paoli Memorial HospitalPaoli, United StatesTaking people
Lahey Clinic PeabodyPeabody, United StatesTaking people
Jefferson Torresdale HospitalPhiladelphia, United StatesTaking people
Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, United StatesTaking people
UPMC Hillman Cancer CenterPittsburgh, United StatesTaking people
South Florida Baptist HospitalPlant City, United StatesTaking people
Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
Oregon Health and Science UniversityPortland, United StatesTaking people
Providence Portland Medical CenterPortland, United StatesTaking people
Providence Saint Vincent Medical CenterPortland, United StatesTaking people
Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
Duke Cancer Center RaleighRaleigh, United StatesTaking people
Corewell Health Reed City HospitalReed City, United StatesTaking people
Beebe Health CampusRehoboth Beach, United StatesTaking people
Aspirus Cancer Care-Rhinelander-James Beck Cancer CenterRhinelander, United StatesTaking people
Virginia Cancer InstituteRichmond, United StatesTaking people
Kaiser Permanente-RosevilleRoseville, United StatesTaking people
Corewell Health William Beaumont University HospitalRoyal Oak, United StatesTaking people
Kaiser Permanente Downtown CommonsSacramento, United StatesTaking people
Kaiser Permanente-South SacramentoSacramento, United StatesTaking people
University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
Regions HospitalSaint Paul, United StatesTaking people
United HospitalSaint Paul, United StatesTaking people
Salina Regional Health CenterSalina, United StatesTaking people
Kaiser Permanente-San FranciscoSan Francisco, United StatesTaking people
Kaiser Permanente-Santa Teresa-San JoseSan Jose, United StatesTaking people
Kaiser Permanente San LeandroSan Leandro, United StatesTaking people
Kaiser San Rafael-GallinasSan Rafael, United StatesTaking people
Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
Essentia Health SandstoneSandstone, United StatesTaking people
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, United StatesTaking people
Kaiser Permanente-Santa RosaSanta Rosa, United StatesTaking people
MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesTaking people
Swedish Medical Center-First HillSeattle, United StatesTaking people
Prisma Health Cancer Institute - SenecaSeneca, United StatesTaking people
Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesTaking people
Sheboygan Physicians GroupSheboygan, United StatesTaking people
Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
VCU Community Memorial Health CenterSouth Hill, United StatesTaking people
MaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland, United StatesTaking people
Kaiser Permanente-South San FranciscoSouth San Francisco, United StatesTaking people
Henry Ford Health Providence Southfield HospitalSouthfield, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesTaking people
Spartanburg Medical CenterSpartanburg, United StatesTaking people
Baystate Medical CenterSpringfield, United StatesTaking people
Mercy Hospital Saint LouisSt Louis, United StatesTaking people
Mercy Hospital SouthSt Louis, United StatesTaking people
Saint Anthony's Hospital Cancer Care CenterSt. Petersburg, United StatesTaking people
Aspirus Cancer Care - Stevens PointStevens Point, United StatesTaking people
Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
Moffitt Cancer CenterTampa, United StatesTaking people
Moffitt Cancer Center - McKinley CampusTampa, United StatesTaking people
Moffitt Cancer Center-International PlazaTampa, United StatesTaking people
Saint Joseph's Hospital/Children's Hospital-TampaTampa, United StatesTaking people
James J Peters VA Medical CenterThe Bronx, United StatesTaking people
Montefiore Medical Center - Moses CampusThe Bronx, United StatesTaking people
Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
Montefiore Medical Center-Weiler HospitalThe Bronx, United StatesTaking people
University of Kansas Health System Saint Francis CampusTopeka, United StatesTaking people
Torrance Memorial Physician Network - Cancer CareTorrance, United StatesTaking people
Munson Medical CenterTraverse City, United StatesTaking people
Corewell Health Beaumont Troy HospitalTroy, United StatesTaking people
Upper Valley Medical CenterTroy, United StatesTaking people
SMC Center for Hematology Oncology UnionUnion, United StatesTaking people
Kaiser Permanente-VallejoVallejo, United StatesTaking people
Essentia Health Virginia ClinicVirginia, United StatesTaking people
Kaiser Permanente-Walnut CreekWalnut Creek, United StatesTaking people
Henry Ford Health Warren HospitalWarren, United StatesTaking people
Henry Ford Madison Heights Hospital - BreastWarren, United StatesTaking people
Henry Ford Warren Hospital - GLCMSWarren, United StatesTaking people
Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
UW Cancer Center at ProHealth CareWaukesha, United StatesTaking people
Aspirus Cancer Care-WausauWausau, United StatesTaking people
Reading HospitalWest Reading, United StatesTaking people
Marshfield Medical Center - WestonWeston, United StatesTaking people
Winter Haven HospitalWinter Haven, United StatesTaking people
Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, United StatesTaking people
UMass Memorial Medical Center - University CampusWorcester, United StatesTaking people
Lankenau Medical CenterWynnewood, United StatesTaking people
University of Michigan Health - WestWyoming, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people

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Trial details

Who runs it: National Cancer Institute (NCI)
Trial code: NCT06498635
Record updated: 6 November 2026
Original description: This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.Read full original descriptionShow less
Randomized Phase III Trial INcorporating Pathologic Complete ReSponse in Participants With Early StaGe Non Small Cell Lung Cancer to Optimize ImmunotHerapy in The AdjuvanT Setting (INSIGHT)
This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.
Inclusion: Participants must have histologically or cytological confirmed diagnosis of clinical stage II-IIIB (excluding clinical N3 disease) non-small cell lung cancer (NSCLC); Participants must have had a complete (R0) resection of NSCLC (with appropriate lymph node sampling as defined by the National Comprehensive Cancer Network [NCCN] guidelines) within 84 days (12 weeks) prior to randomization. Acceptable types of surgical resection are: lobectomy, sleeve resection, bi-lobectomy, or pneumonectomy. Wedge resection is not allowed; Note the NCCN guidelines: N1 and N2 node resection and mapping is a routine component of lung cancer resections. It is recommended at a minimum one N1 and three N2 stations is sampled or complete lymph node dissection. Formal ipsilateral mediastinal lymph node dissection is indicated for participants undergoing resection for N2 disease; Participants must have a pathologic complete response (pCR) (no viable tumor in the resected specimen or lymph nodes), as determined by local pathology review; Participants must have a PD-L1 status result (e.g. [< 1% versus >= 1% or unknown]); Participants must not have known EGFR mutations, or ALK gene fusion; Participants must have received at least two cycles of neoadjuvant platinum-based chemotherapy and anti-PD-1 or anti-PD-L1 therapy. The neoadjuvant treatment must be Food and Drug Administration (FDA) approved and standard of care as listed in NCCN guidelines; Participants must not be planning to receive any concurrent non-protocol directed chemotherapy, immunotherapy, biologic or hormonal therapy for NSCLC treatment while receiving treatment on this study; Participants must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 28 days prior to randomization; Participants must not have medical contraindications or severe adverse events to receiving anti-PD-1 or anti-PD-L1 therapy; Participants must not have received post-operative radiation therapy (PORT) for NSCLC; Participants must not have any unresolved toxicity National Cancer Institute (NCI) CTCAE grade ≥ 2 from previous anticancer therapy with the exception of alopecia, and vitiligo. Note, participants with grade ≥2 neuropathy may be included at the discretion of the treating investigator. Note, participants with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included at the discretion of the treating investigator; Participant must be ≥ 18 years old at time of study entry; Participants must have body weight > 30 kg; Participant must have Zubrod performance status of 0-2; Participant must have a complete medical history and physical exam within 28 days prior to randomization; Hemoglobin > 9.0 g/dL (within 28 days prior to randomization); Absolute neutrophil count ≥ 1.5 x 10\^3/uL (within 28 days prior to randomization); Platelets ≥ 100 x 10\^3/uL (within 28 days prior to randomization); Total bilirubin ≤ 1 x institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin ≤ 5 x institutional ULN (within 28 days prior to randomization); Aspartate transaminase (AST)/alanine transaminase (ALT) ≤ 3 × institutional ULN (within 28 days prior to randomization); Participants must have a calculated creatinine clearance ≥ 40 mL/min using the following Cockcroft-Gault formula. This specimen must have been drawn and processed within 28 days prior to randomization. For creatinine clearance formula see the tools on the Clinical Research Associate (CRA) Workbench https://txwb.crab.org/TXWB/Tools.aspx; Participants must have fully recovered from the effects of prior surgery in the opinion of the treating investigator; Participants with a known history of human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at registration and have undetectable viral load test on the most recent test results obtained within 6 months prior to randomization; Participants with a known history of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy on the most recent test results obtained within 6 months prior to randomization, if indicated; Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load test on the most recent test results obtained within 6 months prior to randomization, if indicated; Participants must not have had an organ transplant; Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participant must not have medical contraindications to receiving immunotherapy, including history of non-infectious pneumonitis that required steroids or active autoimmune disease that has required systemic treatment with disease modifying agents, corticosteroids or immunosuppressive drugs in the past two years. Replacement therapy (e.g. thyroxine for pre-existing hypothyroidism, insulin for type I diabetes mellitus, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. Intra-articular steroid injections are allowed; Participants must not be pregnant or nursing (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method during protocol therapy and for 6 months following completion of protocol therapy with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen. Participants should not breastfeed during protocol therapy and for 6 months following completion of protocol therapy; Participants must not have received a live or live attenuated vaccine within 28 days prior randomization. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever rabies, Bacillus Calmette-Guerin (BCG) and typhoid vaccine. Seasonal influenza vaccines and coronavirus disease 19 (COVID-19) vaccines are allowed, however, intranasal influenza vaccines (e.g. Flu-Mist) are live attenuated, and are not allowed; Participants must be offered the opportunity to participate in specimen banking; Participants who can complete FACT-L, FACT-BRM, and PRO-CTCAE questionnaires forms in English, or Spanish must agree to participate in the patient-reported outcome study; NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system; Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines; For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations.
ClinicalTrials.gov NCT06498635