NCT06503081Completed
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
Investigating the Relationship Between Inflammation and Proteolytic Activity From Mucosa-associated Microbiota in Crohn's Disease Patients
Source: ClinicalTrials.gov · Last updated 22 Aug 2025
Brief summary (registry, in English)
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile. This is clinically important as it may be possible to modulate the proteolytic activity of the CD-associated bacteria by using other bacteria that produce protease inhibitors, such as serpins.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 30 (actual)
- First submitted
- 9 Jul 2024
- Start date
- 1 Dec 2019
- Primary completion date
- 20 Feb 2025
- Lead sponsor
- McMaster University
- Diseases
- Crohn's disease
- NCT number
- NCT06503081
What you commit to
- Study type: Observational
- Participants enrolled: 30
- From 1 Dec 2019 to the primary completion date, 20 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Evidence of toxic megacolon, jaundice, cirrhosis, renal dysfunction, acute GI bleeding
- History of difficult colonoscopy, strictures or extensive diverticulosis
Other
- Inability to provide written informed consent
- Presence of serious life-threatening co-morbidities
- Antibiotics in the last month
- Probiotics in the last week
Who the study is looking for
- Be aged between 18 - 70 years old
- Have a confirmed diagnosis of Crohn's disease
- Have a clinical indication for standard, white light colonoscopy to assess disease activity and extent
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| McMaster University Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.