Comparing self-collected and clinician-collected anal swabs for HPV in people with HIV
Compares self-sampling with clinician sampling for anal HPV in adults over 30 living with HIV.
Plain-language title generated from the registry record
Registry title: Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV
Key facts
- Where
- Saint-Denis and Saint-Pierre, RéunionSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 30 or over who live with HIV. It compares anal HPV swabs taken by the person with swabs taken by a healthcare professional.
- Age
- 30 years or older
- Sex
- All sexes can join.
- Disease stage
- Living with HIV. People with a known current anal cancer cannot join.
Main reasons for not taking part
- Had an anal swab less than 7 days ago
- Known current diagnosis of anal cancer
- Deprived of liberty by judicial or administrative decision
- Minors and people under legal protection (guardianship or curators)
This trial only enrols participants living with HIV. The registry sentence this rests on: living with HIV
Read by machine on 12 November 2026.
Where in Réunion
- CHU de la Réunion Recherche CliniqueSaint-Denis, RéunionContact: Kevin DIALLONot yet recruiting
- CHU de la Réunion Recherche CliniqueSaint-Pierre, RéunionContact: Kevin DIALLOTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre Hospitalier Universitaire de la Réunion
- Trial code
- NCT06507917
- Record updated
- 11 December 2025
- Original description
Anal canal cancers are on the increase in France, with around 2,000 new cases per year. These lesions can be detected by directed biopsies or smear tests.Read full original descriptionShow less
Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV
Anal canal cancers are on the increase in France, with around 2,000 new cases per year. These lesions can be detected by directed biopsies or smear tests.
The incidence rate of anal cancer is 30 times higher in people living with HIV than in the general population.
According to a recent study, the risk of anal cancer is highest in this population, but is also high in heterosexual men over 30 and women over 30. However, the proposal of a proctological examination in this population is not systematic.
In France, there is no HPV screening for people living with HIV, but there is a recommendation for proctology consultation in certain cases, notably for men who have sex with men (MSM) or for women with vaginal cervical lesions.
Several oncogenic HPV serotypes have been identified in the genesis of anal cancer. The serotype identified as the most carcinogenic is HPV-16 (89%).
This study will look at anal HPV screening in people over 30 living with HIV, thus including a population for which no screening is currently offered (heterosexual men living with HIV and women living with HIV without vaginal cervical lesions), and will assess the concordance and acceptability of self-screening versus screening by a healthcare professional as part of a comprehensive anal cancer screening strategy in this population.
Inclusion: Patient :; living with HIV; aged 30 or over; resident on Reunion island and followed at the University Hospital of Reunion Island (the only follow-up center on the island); Able to perform anal self-sampling; Able to answer a questionnaire; Affiliated with or benefiting from a social security scheme; Have given free, informed and signed consent.
Exclusion: People with a previous anal swab less than 7 days old; Persons with a known current diagnosis of anal cancer; Persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curators.