Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era
Key facts
- Where
- Toronto, CanadaSee the site
Where in Canada
- Princess Margaret Cancer CentreToronto, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Health Network, Toronto
- Trial code
- NCT06508567
- Record updated
- 20 October 2026
- Original description
This is an interventional, single-centre, single-arm, non-randomized, prospective, feasibility trial investigating salvage MR-guided High-Dose-Rate brachytherapy for prostate bed recurrence after postoperative radiotherapy.Read full original descriptionShow less
This is an interventional, single-centre, single-arm, non-randomized, prospective, feasibility trial investigating salvage MR-guided High-Dose-Rate brachytherapy for prostate bed recurrence after postoperative radiotherapy.
Inclusion: Patients who received previous RT to the prostate bed +/- pelvic nodal regions; Prostate-bed recurrence identified by biopsy and/or MRI and/or PSMA-PET scan; At least two continuous PSA elevations post RT and PSA above 0.2 ng/dl; With or without ADT PSA doubling time from nadir greater than 6 months; ECOG 0-2; Age greater than 18 years.
Exclusion: History of ≥G3 gastrointestinal (GI) and genitourinary (GU) toxicities following RT; Radiological (e.g. PSMA PET, CT, MRI or bone scan) evidence of or distant metastases; Any contraindications to MR and/or brachytherapy.