Early life factors and bone, muscle and hormone health in young adults
Studies bone, muscle, fat and hormone health in 18-year-olds, linked to early life factors.
Plain-language title generated from the registry record
Registry title: Skeletal Maturation and Endocrine Health in Young Adults
Key facts
- Where
- Aalborg, Aarhus, Copenhagen, Frederiksberg, Holbæk, Hvidovre, Køge, and Odense, DenmarkSee the 9 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 19 years old?
Source: NCT06509776, who can take part
Where in Denmark
- Aalborg University Hospital, Department of EndocrinologyAalborg, DenmarkNo longer taking part
- Aarhus University Hospital, Department of EndocrinologyAarhus, DenmarkNo longer taking part
- Rigshospitalet, Department of Clinical Biochemistry and EndocrinologyCopenhagen, DenmarkNo longer taking part
- Bispebjerg and Frederiksberg Hospital, EEK, Parker InstituteFrederiksberg, DenmarkNo longer taking part
- Holbæk Hospital, Department of MedicineHolbæk, DenmarkNo longer taking part
- Hvidovre Hospital, Department of EndocrinologyHvidovre, DenmarkNo longer taking part
- Zealand University Hospital, Department of MedicineKøge, DenmarkNo longer taking part
- Odense University Hospital, Department of EndocrinologyOdense, DenmarkNo longer taking part
- University of Southern Denmark, Department of Clinical ResearchOdense, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Holbaek Sygehus
- Trial code
- NCT06509776
- Record updated
- 10 January 2025
- Original description
Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors. More surprisingly, perhaps, the genes we inherit from our parents can be modified as a result of influences that affected the health and pregnancy of our mothers and hence the environment experienced in the womb and at birth. The purpose of this study is to investigate which factors are needed for good bone health and hormonal health in young adulthood as well as good muscle mass and normal fat mass, and how this is influenced by factors before birth and by childhood health. Specifically, we will measure bone mass and body composition in young adults (18 years of age) and measure hormones in blood and in hair samples. The clinical visits will be available nationwide at several centers to make participation swift and easy for participants. The changes (known as epigenetic modification) to genes at birth will be studied in dried blood spot samples stored from birth 18 years ago in the Danish Serum Institute and we will use national health registers to identify factors during pregnancy and in childhood that contribute to health effects at age 18.Read full original descriptionShow less
Early Life Determinants of Skeletal Maturation and Endocrine Health in Young Adults - A Nationwide Birth Cohort Study
Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors. More surprisingly, perhaps, the genes we inherit from our parents can be modified as a result of influences that affected the health and pregnancy of our mothers and hence the environment experienced in the womb and at birth. The purpose of this study is to investigate which factors are needed for good bone health and hormonal health in young adulthood as well as good muscle mass and normal fat mass, and how this is influenced by factors before birth and by childhood health. Specifically, we will measure bone mass and body composition in young adults (18 years of age) and measure hormones in blood and in hair samples. The clinical visits will be available nationwide at several centers to make participation swift and easy for participants. The changes (known as epigenetic modification) to genes at birth will be studied in dried blood spot samples stored from birth 18 years ago in the Danish Serum Institute and we will use national health registers to identify factors during pregnancy and in childhood that contribute to health effects at age 18.
Inclusion: Individuals (n = 2000) born in Denmark in 2006 or 2007; Are 18 years old and alive at the time of the clinical examination.
Exclusion: Pregnancy or lactation; No DBS samples available; Lack of consent to use DBS samples or national health registries; Emigration or disappearance.