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NCT06510868Recruiting

Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy

Source: ClinicalTrials.gov · Last updated 5 Mar 2026

Brief summary (registry, in English)

This is a prospective observational study which aims to identify individuals predisposed to developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) could improve patient outcomes in different ways. First, it will enable improved patient selection for PRRT where alternative treatment options are available. Second, understanding the final pathway and how it is modulated by PRRT could allow the design of strategies to halt this process. Third, while it is unknown whether the development of MDS and AML is a late effect of radiopharmaceuticals in general or it is confined to cancer populations or specific radioisotopes will need to be confirmed. Finally, understanding this devastating complication is expected to be the cornerstone towards advancing radiopharmaceuticals' role in the adjuvant setting.

Status (registry)
Recruiting
Study type
Observational
Enrollment
45 (estimated)
First submitted
12 Jul 2024
Start date
1 Aug 2024
Primary completion date
1 Apr 2028
Lead sponsor
University Health Network, Toronto
NCT number
NCT06510868

What you commit to

  • Study type: Observational
  • Planned participants: 45
  • From 1 Aug 2024 to the primary completion date, 1 Apr 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Unwillingness to provide blood sample and follow up as per protocol

Who the study is looking for

  • ECOG 0-3
  • Life expectancy \> 6 months
  • Informed consent and willingness to undergoing serial genetic panel CHIP testing.
  • Cohort Specific criteria
    • Cohort A: PRRT completed within 5 years of enrolment
    • Cohort B: PRRT planned to commence within 4 months of enrolment
    • Cohort C: diagnosis of MDS or AML following prior PRRT.

Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Princess Margaret Cancer Centre
Coordinator of this site? Confirm its status
TorontoCanadaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.