NCT06510868Recruiting
Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
This is a prospective observational study which aims to identify individuals predisposed to developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) could improve patient outcomes in different ways. First, it will enable improved patient selection for PRRT where alternative treatment options are available. Second, understanding the final pathway and how it is modulated by PRRT could allow the design of strategies to halt this process. Third, while it is unknown whether the development of MDS and AML is a late effect of radiopharmaceuticals in general or it is confined to cancer populations or specific radioisotopes will need to be confirmed. Finally, understanding this devastating complication is expected to be the cornerstone towards advancing radiopharmaceuticals' role in the adjuvant setting.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 45 (estimated)
- First submitted
- 12 Jul 2024
- Start date
- 1 Aug 2024
- Primary completion date
- 1 Apr 2028
- Lead sponsor
- University Health Network, Toronto
- NCT number
- NCT06510868
What you commit to
- Study type: Observational
- Planned participants: 45
- From 1 Aug 2024 to the primary completion date, 1 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Unwillingness to provide blood sample and follow up as per protocol
Who the study is looking for
- ECOG 0-3
- Life expectancy \> 6 months
- Informed consent and willingness to undergoing serial genetic panel CHIP testing.
- Cohort Specific criteria
- Cohort A: PRRT completed within 5 years of enrolment
- Cohort B: PRRT planned to commence within 4 months of enrolment
- Cohort C: diagnosis of MDS or AML following prior PRRT.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.