NCT06512935Recruiting
Ventilator Pressure and Optimization of Compliance and Hemodynamics
Ventilator Pressure and Optimization of Compliance and Hemodynamics: VPOCH Trial
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants. Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 5 Jul 2024
- Start date
- Oct 2026
- Primary completion date
- May 2027
- Lead sponsor
- University of Alabama at Birmingham
- NCT number
- NCT06512935
What you commit to
- Study type: Interventional
- Planned participants: 24
- From Oct 2026 to the primary completion date, May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cyanotic or ductal-dependent congenital heart disease
- Newborns on pressors or steroids for maintaining cardiac output
- Non-invasive ventilation or newborn with significant BPD (bronchopulmonary dysplasia) with pulmonary hypertension (HTN)
Other
- Blood culture-positive sepsis
- Congenital anomalies affecting respiration
- Newborns who are considered too unstable for study enrolment per neonatology attending
- Open skin wounds or abrasions on the chest wall.
Who the study is looking for
- Preterm infants with recovering respiratory distress syndrome (RDS) who were born at a gestational age \< 34 weeks and are receiving respiratory support via conventional mechanical ventilation or on HFJV.
- Post-natal age \> 7 days and less than 1 month (outside golden week protocol)
- Gestational age ≥ 21 weeks and ≤ 34 week
- Infants with written informed consent obtained from legal guardian
Age in the registry: 7 days to 30 days · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Univerisity of Alabama Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.