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Not yet recruitingPhase 4

Platelet-rich plasma injected into bone or joint for advanced knee osteoarthritis

Compares platelet-rich plasma injected into bone versus the joint in advanced knee osteoarthritis.

Key facts

Who runs it
Universidade do Porto
Where
Portugal1 site in 1 countryChoose a country to see its sites
Trial code
Registry title
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
Status
Not yet recruiting
Phase
Phase 4
People taking part
50 people, planned
Started
1 Jan 2025
Expected to end
31 Oct 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration
Record updated
6 August 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 45 or older with advanced knee osteoarthritis (wear-and-tear arthritis) in one or both knees. It compares two ways of injecting PRP, a treatment made from the person's own blood.

Age
45 Years and older
Sex
All sexes can join
Disease stage
Knee osteoarthritis with symptoms for more than 3 months. X-rays must show Kellgren-Lawrence grade III or IV, which are advanced stages. People must be able to walk, even if the knee hurts.
Earlier treatment
No knee surgery ever. No NSAIDs (common anti-inflammatory painkillers) in the 3 days before the injections. No regular corticosteroid (steroid) use in the last 3 months. No other injections into the knee joint in the past 6 months.

Main reasons for not taking part

  • Any past knee surgery
  • Autoimmune or rheumatic disease affecting the whole body
  • Blood platelet disorders
  • NSAID use in the 3 days before the injections
  • Regular steroid use in the last 3 months, or other knee joint injections in the past 6 months

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Adult individuals with unilateral or bilateral symptomatic knee OA diagnosis according to the American College of Rheumatology
  • with symptoms for more than 3 months
  • confirmed with radiologic diagnosis (Kellgren-Lawrence grades III or IV)
  • Patients must be able to walk with a painful knee

Who cannot take part

  • previous history of knee surgery
  • use of NSAIDs 3 days prior the injections
  • previous history (last 3 months) of systematic use of corticosteroids
  • systemic autoimmune or rheumatic disease
  • platelet diseases
  • or other intra-articular injections in the knee in the past 6 months

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic). Patients will be selected with the aim of matching for important confounders (sex and age) the grade of knee OA will be restricted to advance stages.

The 2 groups in the trial

  • Intraosseous and intra-articular PRPExisting treatment, for comparison

    Two intraosseous injections of PRP and another intra-articular injection of PRP on the same day.

    Treatment: Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration

  • Intra-articular PRPExisting treatment, for comparison

    Patients submited to two intra-articular injections of PRP, separated by one week.

    Treatment: Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Comparison of Efficacy of Intraosseous vs Intra-articular Injections of PRP for Advanced Knee OA
Plain-language title
Platelet-rich plasma injected into bone or joint for advanced knee osteoarthritisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
6 August 2024
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma (NCT06520059) – Frontlight Research