Tests surovatamig in adults with returned B-cell non-Hodgkin lymphoma

Trial details

Who runs it

AstraZeneca

Trial code

NCT06526793EU 2023-505789-27-00

Record updated

14 October 2026

Original description

This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of surovatamig (AZD0486) monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least two prior lines of therapies. The study has 2 Modules: Module 1 for FL and Module 2 for LBCL.Read full original descriptionShow less

A Modular Phase 2, Single-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Surovatamig (AZD0486) in Participants With Relapsed or Refractory (R/R) B-cell Non-Hodgkin Lymphoma (SOUNDTRACK-B)

This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of surovatamig (AZD0486) monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least two prior lines of therapies. The study has 2 Modules: Module 1 for FL and Module 2 for LBCL.

Key Inclusion Criteria:; Aged 18 years old and above; Histologically confirmed relapsed refractory FL (Module 1) and LBCL (Module 2) after at least 2 prior lines of therapy; ECOG performance status 0 to 2; Locally confirmed CD-19 expression in lymphoma cells after progression from last CD 19 directed therapy; FDG-avid disease with at least one bi-dimensionally measurable nodal lesion (defined as > 1.5 cm in its longest dimension), or extranodal lesion (defined as > 1.0 cm in its longest dimension); Adequate hematological function: ANC ≥ 1000/mm3, platelets; 75,000/mm3, hemoglobin ≥ 9 g/dL. Transfusion and/or growth factor are allowed but counts must be stable for at least 72 hours afterwards prior to screening; Adequate liver function: total bilirubin <1.5x ULN, AST/ALT ≤ 3xULN or < 5 × ULN in the presence of lymphoma involvement of the liver; Adequate renal function: creatinine clearance (CrCl) of ≥ 45 mL/min; Adequate cardiac function, defined as left ventricular ejection fraction (LVEF) ≥ 45% by echocardiogram or MUGA; The above is a summary, other inclusion criteria details may apply; Key Exclusion Criteria:; Diagnosis of CLL, Burkitt lymphoma, or Richter's transformation; Active CNS involvement by B-NHL; Leukemic presentation of B-NHL; History of a clinically relevant CNS medical condition or pathology that required treatment in the preceding year, is currently symptomatic, or that the treating investigator considers to have the potential to interfere with the evaluation of safety, such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia, neurodegenerative disorder including Parkinson's disease, cerebellar disease, organic brain syndrome, psychosis or other severe mental illness; Prior therapy with T-cell engager (TCE) within 8 weeks, autologous Hematopoietic Stem Cell Transplantation (HSCT) within 12 weeks, CAR T- cell therapy within 6 months, or prior allogeneic HSCT within 24 weeks of first dose of surovatamig; Requires chronic immunosuppressive therapy; Unresolved non hematological AEs ≥ Grade 2 from prior therapies; history of ≥ Grade 3 CRS or neurotoxicity from prior CAR-T or TCE therapy; History of major cardiac abnormalities; If female, participant must not be pregnant or breastfeeding; The above is a summary, other exclusion criteria details may apply.

ClinicalTrials.gov NCT06526793 · EU CTIS 2023-505789-27-00