Investigation of the Effect of Movement Mobilization Concept on Sensory, Pain, Muscle Activation in Patients With Knee Osteoarthritis
Key facts
- Who runs it
- Istinye University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 36 people enrolled
- Started
- 25 Jul 2024
- Ended
- 10 Oct 2025
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Movement Mobilization Concept, Exercise and Tape
- Sham Movement Mobilization Concept, Exercise and Tape
- Special Exercises
- Record updated
- 21 January 2026
Who can take part
- Age
- 45 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 17 criteriaShow less
Who can take part
- Diagnosing knee OA according to the American College of Rheumatology (ACR) criteria (Primary knee OA diagnosis)
- Stage 2 or 3 patients according to Kellgren-Lawrence radiological staging criteria
- Patients with a disease duration of 6 months or longer
- Participants aged between 50 and 70
- Being able to walk without using assistive devices
- Body mass index is below 35 kg/m²
- Pain intensity must be between 3 and 7 according to the Numerical Pain Rating Scale
- Not having received physiotherapy in the last year
Who cannot take part
- Infiltration with steroids or local anesthetics in the year before the patient entered the study or during follow-up
- Obtaining the indication for surgery
- Having a lower extremity deformity (severe varus or valgus deformity, significant joint instability and other orthopedic problems requiring surgical intervention)
- Severe hearing, vision and speech impairment
- Having serious systemic and cardiovascular diseases that prevent exercise
- Having a neurological disease
- Having any disorder, syndrome or disease that may cause myofascial or neuropathic pain in the lower extremities, such as lumbar radiculopathy, meralgia paresthetica or Saphenous nerve compression
- Cognitive deficit (Alzheimer's, dementia) revealed in the clinical history
- Patients with acute knee inflammation
This trial has no sites in United States.
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About the trial
What the trial wants to find out
Individuals with knee osteoarthritis are one of the groups most affected by musculoskeletal disorders and experience pain and mobility limitations that significantly limit their daily living activities. Quantitative sensory assessment in individuals with osteoarthritis plays a critical role in evaluating disease progression and treatment effectiveness by objectively measuring changes in sensory perception such as proprioception and nociception. These changes in sensory perception can negatively affect individuals' movement control and balance. In this context, evaluation of quantitative sensory parameters allows the development of more targeted and effective interventions in the rehabilitation processes of individuals with osteoarthritis.
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Additionally, electromyographic evaluation in individuals with osteoarthritis analyzes muscle activation levels, providing a better understanding of the impairments in muscle functions of these individuals. EMG data helps to design rehabilitation programs individually by determining to what degree muscles are activated and which muscle groups are more affected. Decreased muscle activation or abnormal muscle activation in individuals with osteoarthritis can negatively affect joint stability and mobility. Therefore, EMG evaluations are an objective method to evaluate the effectiveness of treatment strategies aimed at restoration of muscle functions in individuals with osteoarthritis.
The quantitative sensory and EMG evaluations performed in this project aim to improve the quality of life of individuals by offering innovative approaches in the clinical management of individuals with osteoarthritis. Therefore, these evaluations are of critical importance for the original value and scientific contribution of our project. For these reasons, the selection of individuals with osteoarthritis and the detailed evaluations made on these individuals and its connection with the methods can be considered as the innovative and original aspect of our project.
The aim of this study is to investigate the effect of the Mulligan movement mobilization concept on quantitative sensory parameters, pain and muscle activation levels in patients with knee osteoarthritis.
The 3 groups in the trial
- Movement Mobilization Concept GroupTreatment being tested
MWM and appropriate taping will be applied to the cases included in the Mulligan group, according to the Mulligan Concept, and home exercises will be given to the patient as recommended by the concept.
Treatment: Movement Mobilization Concept, Exercise and Tape
- Sham Movement Mobilization Concept GroupSham treatment, for comparison
The technique will be applied to cases in the sham group with only hand contact, without any slippage or rotation in any direction. Then, rigid taping will be applied without any tension or direction, and home exercises will be given.
Treatment: Sham Movement Mobilization Concept, Exercise and Tape
- Control GroupExisting treatment, for comparison
Subjects in the control group will be shown home exercises customized for knee osteoarthritis and asked to continue them.
Treatment: Special Exercises
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Investigation of the Effect of Movement Mobilization Concept on Quantitative Sensory Parameters, Pain, Muscle Activation Levels in Patients With Knee Osteoarthritis
- Record updated
- 21 January 2026