NCT06528964Recruiting
Proteinopathies Expression in Skin of Neurodegenerative Disorders
Expression of Proteinopathies in Skin Biopsies of Patients With Neurodegenerative Disorders
Source: ClinicalTrials.gov · Last updated 16 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 \[TDP43\]) in skin biopsies of patients with a neurodegenerative disease like Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus. The main question it aims to answer is: * Is there a specific pattern of aggregation of proteinopathies in skin biopsies in each neurodegenerative disease in comparison to healthy control subjects? Skin biopsies will be analyzed using immunohistochemistry and immunofluorescence for detection of alpha-synuclein, amyloid-beta, phosphorylated tau and TAR DNA binding protein 43, and the aggregation patterns will be compared between patients with a neurodegenerative disease vs patient with normal pressure hydrocephalus vs healthy control subjects.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 25 Jul 2024
- Start date
- 20 Dec 2023
- Primary completion date
- 25 Oct 2026
- Lead sponsor
- Universidad Autonoma de San Luis Potosí
- NCT number
- NCT06528964
What you commit to
- Study type: Observational
- Planned participants: 40
- From 20 Dec 2023 to the primary completion date, 25 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia
- Patients or controls that a diagnosed skin disease
- Patients that have an "atypical" presentation of the disease
Other
- Patients in which the diagnosis is not clear or hasn't been confirmed
- Patients or controls that have a neuroinfection
- Patients or controls that have diagnosis of a coagulopathy
Who the study is looking for
- Patients 45 years and older
- Men and women
- Patients diagnosed with Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus
- Patients that voluntarily accept to participate in the study and accept the consent form
- People 45 years and older
- Men and women
- Subjects can be related to a patient but not by blood (for example spouse of a patient)
- Subjects don't have direct family history of a neurodegenerative control
- Subjects don't have any clinical findings suggesting dementia
- Subjects voluntarily accept to participate in the study and accept the consent form
Age in the registry: 45 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Central Dr. Ignacio Morones Prieto Coordinator of this site? Confirm its status | San Luis Potosí City | Mexico | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.