Tests radiotherapy added after chemo-immunotherapy in extensive small-cell lung cancer
Tests radiation after chemo-immunotherapy in adults with advanced small-cell lung cancer.
Plain-language title generated from the registry record
Registry title: Radiotherapy Strategies for Use in Combined Treatment of Small-cell Lung Cancer
Key facts
- Where
- Lodz and Lublin, PolandSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with extensive-stage small cell lung cancer whose disease has shrunk or stayed stable after platinum chemotherapy with durvalumab or atezolizumab. It tests adding radiotherapy.
- Age
- 18 years or older
- Sex
- Men and women can join.
- Disease stage
- Small cell lung cancer confirmed by tissue or cell tests, extensive stage (stage IV). Some disease must remain after chemo-immunotherapy. Up to 10 metastatic lesions. Brain metastases must be clinically controlled.
- Earlier treatment
- Must have had platinum-based chemotherapy with durvalumab or atezolizumab, with partial response or stable disease. Prior chest radiotherapy that prevents safe study radiotherapy is not allowed. Prior palliative radiotherapy to metastatic sites is allowed.
Main reasons for not taking part
- Other uncontrolled cancers
- Active autoimmune disease, except diabetes, hypothyroidism, psoriasis, eczema, lichen planus and vitiligo
- Grade 2 or greater pneumonitis caused by immunotherapy
- Taking part in another clinical trial
- Premenopausal women who do not accept effective contraception
Read by machine on 9 November 2026.
Where in Poland
- Copernicus Memorial Hospital in ŁódźLodz, PolandTaking people
- Center of Oncology of the Lublin Region St. Jana z Dukli in LublinLublin, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copernicus Memorial Hospital
- Trial code
- NCT06529081
- Record updated
- 28 August 2025
- Original description
The purpose of this study is to evaluate the efficacy of radiotherapy as part of the combined treatment approach for patients diagnosed with histopathologically confirmed small cell lung cancer (SCLC) in the advanced stage of extensive disease (ED) who are undergoing chemo-immunotherapy. The planned study aims to assess the impact of incorporating consolidative radiotherapy into the treatment strategy, focusing on residual changes following chemo-immunotherapy (during immunotherapy) and its effect on progression-free survival.Read full original descriptionShow less
Assessment of Radiotherapy Strategies for Use in Combined Treatment of Small-cell Lung Cancer at the Stage of Extensive Disease - a Research Experiment
The purpose of this study is to evaluate the efficacy of radiotherapy as part of the combined treatment approach for patients diagnosed with histopathologically confirmed small cell lung cancer (SCLC) in the advanced stage of extensive disease (ED) who are undergoing chemo-immunotherapy. The planned study aims to assess the impact of incorporating consolidative radiotherapy into the treatment strategy, focusing on residual changes following chemo-immunotherapy (during immunotherapy) and its effect on progression-free survival.
This research experiment will be conducted as a randomized multi-center study, comprising the following treatment arms:
* Arm I: Continuation of standard of care - PDL1/PD1 immunotherapy (durvalumab or atezolozumab) after chemo-immunotherapy based on platinum compounds; * Arm II: Standard of care, followed by consolidating radiotherapy of the chest area and possibly metastases (if indicated) in doses and for palliative indications (total dose of 30 Gy in 10 daily doses of 3 Gy each); * Arm III: Standard of care, followed by consolidating radiotherapy in the radical/ablative doses (total dose of 45 Gy delivered in 15 daily fractions of 3 Gy for the chest area, and total dose of 24 Gy in single fractions of 8 Gy administered every 2-3 days for the metastatic lesions) of the chest area and all metastatic lesions.
Additionally, as part of routine weekly blood collections, an extra volume of 10 ml of blood will be collected. This additional blood sample will be obtained before starting radiotherapy, during each week of radiotherapy (maximum three collections), and at the time of disease progression (one collection), resulting in a total of five extra samples. The collected blood will be prepared, stored and used for circulating tumor DNA (ctDNA) testing, according to the protocol. The ctDNA analysis data will be utilized as a potential marker to determine the time to progression and assess the benefits derived from the administered radiotherapy.
Inclusion: Histopathological confirmation of small cell lung cancer based on histological or cytological examination; Primary clinical stage: Extensive stage of the disease according to VASLG classification or stage IV according to TNM classification; Eastern Cooperative Oncology Group (ECOG) performance status 0-2 prior to randomization; Partial response (PR) or stable disease (SD) to platinum-based doublet chemotherapy with durvalumab or atezolizumab based on restaging (positron emission tomography [PET]/computed tomography [CT] or CT or magnetic resonance imaging [MRI]); Ability to undergo radiotherapy at a total dose of 45 Gy in 15 daily fractions of 3 Gy to the chest area and a total dose of 24 Gy administered in single fractions every 2-3 days of 8 Gy to the metastatic lesions; Clinical control of brain metastases (prior whole-brain irradiation at any stage is acceptable before study entry); Measurable residual disease after chemioimmunotherapy (according to RECIST 1.1 solid tumor response assessment criteria) or in case of CR/PR presence of tumor lesions not classified as measurable; Volume and number (up to 10) of metastatic lesions allowing for radiotherapy in doses according to the study protocol; Absence of clinically significant and uncontrolled co-morbidities with pharmacological treatment; Absence of active autoimmune diseases except for diabetes, hypothyroidism, psoriasis, eczema, lichen planus, and vitiligo; Adequate hematopoietic function allowing treatment with atezolizumab or durvalumab, according to the current SmPC (Summary of Product Characteristics); Renal and hepatic function allowing treatment according to the current SmPC for atezolizumab or durvalumab.
Exclusion: Premenopausal women who do not accept the need for effective contraception during radiotherapy and/or chemotherapy/immunotherapy; Prior chest radiotherapy that precludes safe administration of radiotherapy according to the study protocol. Prior palliative radiotherapy to metastatic sites is acceptable before study entry if clinically indicated as determined by the physician; Contraindications to radiotherapy according to the approved protocol; Coexistence of other uncontrolled malignant neoplasms; Grade 2 or greater CTCAE v.5 pneumonitis secondary to immunotherapy; Age under 18 years old; Individuals excluded from participation in a medical experiment based on Article 23A(1) of the Act on the Profession of Physician and Pharmacist; Contraindications to the use of atezolizumab or durvalumab as specified in the SmPC; Participation in another clinical trial during the study.