NCT06529744Recruiting
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Source: ClinicalTrials.gov · Last updated 20 Nov 2025
Brief summary (registry, in English)
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 29 Apr 2024
- Start date
- 11 Nov 2023
- Primary completion date
- Nov 2026
- Lead sponsor
- University Health Network, Toronto
- NCT number
- NCT06529744
What you commit to
- Study type: Observational
- Planned participants: 500
- From 11 Nov 2023 to the primary completion date, Nov 2026
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Who the study is looking for
- Possible or probable diagnosis of MCI or early dementia
- Age 30-95
- Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
- Must, in the opinion of the site investigator, be able to complete most study procedures.
Age in the registry: 30 years to 95 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baycrest Coordinator of this site? Confirm its status | North York | Canada | Not yet recruiting |
| Toronto Western Hospital, University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Centre for Addiction and Mental Health Coordinator of this site? Confirm its status | Toronto | Canada | Not yet recruiting |
| Sunnybrook Health Sciences Centre Coordinator of this site? Confirm its status | Toronto | Canada | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.