Exercise training for chest pain with no coronary artery narrowing
Tests whether exercise training helps adults over 50 with chest pain and no coronary narrowing.
Plain-language title generated from the registry record
Registry title: Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Key facts
- Where
- Copenhagen and Frederiksberg, DenmarkSee the 2 sites
Where in Denmark
- Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000Copenhagen, DenmarkNot yet recruiting
- Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57Frederiksberg, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Bispebjerg Hospital
- Trial code
- NCT06529848
- Record updated
- 21 February 2025
- Original description
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function.Read full original descriptionShow less
Ischemia With No Obstruction of Coronary Arteries: Underlying Mechanisms and the Impact of Exercise Training (EXINOCA)
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function.
Hypotheses:
The first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body.
The second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.
Inclusion: Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) < 2.5 or hyperemic myocar-dial blood flow (hMBF)<2.3 ml/g/min using [15O]H2O-PET; No obstructive coronary artery disease.
Exclusion: Uncontrolled hypertension defined as blood pressure above target 140/90 for all; Heart failure, defined as left ventricular ejection fraction of less than 40%; Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile; Co-morbidity resulting in <1 year expected survival; Considered by the investigator, for any reason, to be an un-suitable candidate for the study; Unable or unwilling to exercise, e.g. due to arthritis or in-jury*; Already are regularly physically active and/or have a maxi-mal oxygen uptake >45 ml/kg/min.