Finding causes of chest pain when heart arteries look clear
Studies chest pain in people whose heart arteries show no narrowing, using PET imaging.
Plain-language title generated from the registry record
Registry title: Mechanisms Behind Microvascular Dysfunction in INOCA
Key facts
- Where
- Copenhagen, DenmarkSee the site
Where in Denmark
- Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000Copenhagen, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Bispebjerg Hospital
- Trial code
- NCT06529861
- Record updated
- 31 July 2024
- Original description
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.Read full original descriptionShow less
Identification of Mechanisms Behind Microvascular Dysfunction in Ischemia With No Obstructive Coronary Artery Disease
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
Inclusion: Only for angina patients: Have CMD, defined as myocardial bloodflow re-serve (MBFR) < 2.5 or hyperemic myocardial blood flow (hMBF) < 2.3ml/g/min.
Exclusion: Uncontrolled hypertension defined as blood pressure above target 140/90 for all; The subject has a known allergy to either: norepinephrine, adenosine, ketorolac, and or ascorbic acid (vitamin C); Heart failure, defined as left ventricular ejection fraction of less than 40%; Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile; Co-morbidity resulting in <1 year expected survival; Considered by the investigator, for any reason, to be an unsuitable candidate for the study; Unable or unwilling to exercise, e.g. due to arthritis or injury*; Already are regularly physically active and/or have a maximal oxygen uptake >45 ml/kg/min.