Studies tiny blood clots and immune cells in people with stroke risk
Looks at tiny blood clots and activated neutrophils in adults with ischemic stroke.
Plain-language title generated from the registry record
Registry title: Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Key facts
- Where
- Zurich, SwitzerlandSee the site
Where in Switzerland
- University Hospital ZurichZurich, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Zurich
- Trial code
- NCT06530927
- Record updated
- 29 August 2025
- Original description
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50% of patients with successful recanalization remain severely disabled despite successful recanalization, a scenario called "futile recanalization". One of the causes for this lack of treatment effect is capillary obstruction, or "no reflow", potentially resulting from activated neutrophils and micrometer-sized blood clots. To address this issue, we employ digital holotomographic and atomic force microscopy to investigate the structural and chemical characteristics of blood and clot material in stroke patients and individuals at high risk of developing a stroke. Our study elucidates the association of activated neutrophils and microclots with stroke risk, and may be associated with clinical outcome, stroke ethology and reperfusion failure in patients with stroke. Leveraging label-free microscopy tools, could potentially lead to the discovery of new biomarkers for individualized stroke treatment and prevention, ultimately offering rapid identification of at risk patients and improving clinical outcomesRead full original descriptionShow less
Micro-clots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure The CLOTSAFE - Study (Micro-CLOTs, Stroke Risk, Activated Neutrophils, Reperfusion FailurE)
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50% of patients with successful recanalization remain severely disabled despite successful recanalization, a scenario called "futile recanalization". One of the causes for this lack of treatment effect is capillary obstruction, or "no reflow", potentially resulting from activated neutrophils and micrometer-sized blood clots. To address this issue, we employ digital holotomographic and atomic force microscopy to investigate the structural and chemical characteristics of blood and clot material in stroke patients and individuals at high risk of developing a stroke. Our study elucidates the association of activated neutrophils and microclots with stroke risk, and may be associated with clinical outcome, stroke ethology and reperfusion failure in patients with stroke. Leveraging label-free microscopy tools, could potentially lead to the discovery of new biomarkers for individualized stroke treatment and prevention, ultimately offering rapid identification of at risk patients and improving clinical outcomes
Inclusion: Patients without acute stroke CS or CSG; No previous stroke or previous stroke ≥ 1 year ago; Signed informed consent; Patients with acute stroke (AS-noTx, AS-IVT, AS-MT):; Patients admitted with high suspicion of acute ischemic stroke; Time of onset of stroke symptoms ≤ 12 hours; Consent according to the regulations of research in an emergency situation; Ischemic stroke later confirmed.
Exclusion: Acute treatment with IVT or with MT; Acute Stroke IVT-Group • Acute treatment with MT or without IVT; Acute Stroke MT-Group; Age under 18 years; Acute Stroke no Therapy; All groups:; Pregnancy; Acute treatment without MT.