The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Key facts
- Where
- Ar Ramtha and Irbid, JordanSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 55 years old?
Source: NCT06532851, who can take part
Where in Jordan
- King Abdullah University HospitalAr Ramtha, JordanContact: Khaldoon Bashaireh, MDTaking people
- Jordan University of Science and TechnologyIrbid, JordanContact: Mohammad Yabroudi, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Jordan University of Science and Technology
- Trial code
- NCT06532851
- Record updated
- 12 May 2026
- Original description
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.Read full original descriptionShow less
The Efficacy of Progressive Resistance Exercises Versus Aerobic Exercises on Cartilage Morphology and Physical Function in Patients With Degenerative Meniscus Tear: A Randomized Controlled Trial
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.
Inclusion: Are between 35 and 55 years of age; Have a symptomatic degenerative medial meniscus tear as evidenced by:; Presence of medial knee pain; Medial joint line tenderness; Pain and limited motion when attempting to perform a full squat and; Increased intra-meniscal signal on at least 2 consecutive MRI slices and; Have clearance from their personal physician to participate in an exercise program.
Exclusion: Prior or current ligament injury or surgery of the involved knee; Prior or current injury or surgery to contra-lateral knee; Had prior surgery for an aneurysm; any medical illness that may interfere with the patient's general fitness or exercise capability; Had surgery within the past two months; An inflammatory arthritic condition or; Any injury or condition involving the lower extremities that affects their ability to walk; Because participation in this study requires undergoing MRI, subjects will be excluded if they:; Have a cardiac pacemaker; Radiographic evidence of OA (K-L grade 2 or above); A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus); A meniscus injury that requires meniscectomy (locked knee); Pathological ligamentous laxity upon examination of the knee; If female, pregnant at the time of enrollment; Had any contraindication with MRI.