Brain-timed magnetic stimulation to help hand recovery after stroke
Tests timed magnetic brain stimulation to aid hand movement in adults recovering from stroke.
Plain-language title generated from the registry record
Registry title: Real-time Personalized Brain State-dependent TMS After Stroke
Key facts
- Where
- Iowa City, United StatesSee the site
Where in United States
- University of IowaIowa City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sara Hussain
- Trial code
- NCT06533176
- Record updated
- 2 November 2026
- Original description
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and upper extremity motor impairment.Read full original descriptionShow less
Towards Real-time Personalized Brain State-dependent TMS to Enhance Poststroke Hand Rehabilitation
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and upper extremity motor impairment.
-Presence of residual upper extremity hemiparesis, defined as any of the following: Fugl Meyer Upper Extremity Score <66, Wolf Motor Function Test Score <70, Affected hand performance on the 9-Hole Peg Test >= 10% worse than unaffected hand, Affected hand pinch, key, or power grip performance >= 10% worse than unaffected hand,; Occurrence of ischemic or hemorrhagic stroke >= 6 months before participation; Mini Mental State Exam score > 24; Willingness and ability to provide informed consent; No history of neurological disease and/or neurological injury other than stroke; No TMS contraindications, including but not limited to:; Cardiac pacemaker, Cochlear implant, Cortical stimulator, Deep brain stimulator, Vagus nerve stimulator, Cervical spine epidural stimulation, Ventriculoperitoneal shunt, Ferromagnetic metallic implants above the level of the seventh cervical vertebra, Seizure in the last 12 months while taking anti-epilepsy medication, History of adverse reactions to TMS or peripheral nerve stimulation, Current, suspected, or planned pregnancy, Any recent changes (within the last month) to medication use; Presence of residual corticospinal connections innervating an affected upper extremity muscle following stimulation of the lesioned hemisphere (i.e., MEP+), evaluated at rest.