EJV Occlusion Pressure Measurement to Assess Intravascular Volume in Cirrhotic Patients During IV Albumin Substitution
Key facts
- Who runs it
- Insel Gruppe AG, University Hospital Bern
- Where
- Switzerland1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 20 people enrolled
- Started
- 17 Jul 2024
- Ended
- 7 May 2025
- Type of study
- Interventional
- Treatments tested
- CPMX2
- Record updated
- 19 June 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- In- and outpatients with liver cirrhosis of any etiology, diagnosed by either liver histology or compatible biochemical, imaging and clinical parameters, being treated at the department of Visceral Surgery and Medicine at Inselspital Bern, University Hospital Bern, Switzerland
- Age ≥ 18 years
- Indication for IV albumin infusion according to current EASL guidelines[11] and BAVENO VII consensus recommendations[12] including large volume paracentesis, spontaneous bacterial peritonitis (SBP), AKI with/without HRS
- Available transthoracic echocardiography assessing right heart function within maximum 3 months from study inclusion
Who cannot take part
- History of right heart failure
- Anatomic IVC abnormalities, such as IVC stenosis and/or thrombosis
- History of orthotopic liver transplant
- Patients admitted to intermediate care unit or intensive care unit at the time of albumin infusion
- Previous IV albumin infusion within the last 5 days
- Contraindication to albumin infusion (i.e. anaphylactic reactions against albumin)
- Contraindication to the PLR test (i.e. increased intracranial pressure)
- Clinical evidence of lung edema, hemodynamic instability/shock
- Patients unable to provide informed consent
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Cirrhotic patients with an indication for intravenous albumin will undergo a venous compression technique of the external jugular vein plus an ultrasound examination before/after passive leg raise as well as before/after intravenous albumin infusion in order to study the dynamics of the intravascular volume status and to rule out volume overload.
The group in the trial
- CPMX2 ArmOther group
This study is a single-center, single arm, prospective, exploratory proof of concept study. Cirrhotic patients with an indication for intravenous albumin will undergo a venous compression technique of the external jugular vein plus an ultrasound examination before/after passive leg raise as well as before/after intravenous albumin infusion in order to study the dynamics of the intravascular volume status and to rule out volume overload.
Treatment: CPMX2
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Measurement of Occlusion Pressure of the External Jugular Vein for Intravascular Volume Assessment in Cirrhotic Patients During Intravenous Albumin Substitution.
- Record updated
- 19 June 2025