Checking heart arteries with CT scans after neck artery treatment
Studies CT heart scans to guide heart treatment in people with neck artery narrowing.
Key facts
- Who runs it
- Pauls Stradins Clinical University Hospital
- Where
- Riga, LatviaSee the site
- Trial code
- Registry title
- Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial)
- Status
- Recruiting
- People taking part
- 300 people, planned
- Started
- 25 Jun 2024
- Expected to end
- 25 Jun 2029
- Type of study
- Observational, 2 groups
- Treatments tested
- Coronary CT angiography and FFRct analysis
- Record updated
- 9 August 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 or older with narrowing of the neck (carotid) artery who had it opened successfully in the past 14 days and have no known heart artery disease.
- Age
- 50 years or older
- Sex
- All sexes
- Disease stage
- Narrowing of the carotid artery, with or without symptoms, treated successfully by endarterectomy or stenting within the past 14 days. People with symptoms must have at least Rankin III.
- Earlier treatment
- Carotid endarterectomy or stenting within the past 14 days. No prior coronary stent or bypass surgery.
Main reasons for not taking part
- Known coronary artery disease, past heart attack, or prior coronary stent or bypass
- Heart rhythm problems such as 2nd or 3rd degree heart block, sick sinus syndrome, long QT syndrome, severe arrhythmia, pacemaker or defibrillator
- Severe asthma, or severe or bronchodilator-dependent COPD
- Severe heart failure (NYHA III or IV) or kidney function with EPI-GFR below 30 ml/min
- Pregnancy, or unknown pregnancy status in a person who could become pregnant
The registry criteria, word for word
Show all 19 criteriaShow less
Who can take part
- Inform consent obtained before any study-related activities
- Age above or equal to 50 years with symptomatic or asymptomatic critical carotid stenosis (symptomatic patients with at least Rankin III) which has been successfully revascularized by carotid endarterectomy or stenting within the past 14 days
- Willing and able to undergo coronary CTA scan within 14 days of randomization and agrees to submission of CTA data set for HeartFlow FFRct analysis with results made available to treating physician
Who cannot take part
- Known CAD, history of MI, prior coronary revascularization (PCI or CABG)
- Severe arrhythmia, prior pacemaker or internal defibrillator lead implantation
- Participation in any interventional clinical study within 30 days prior to screening
- History of severe asthma, severe or bronchodilator-dependent Chronic obstructive pulmonary disease (COPD)
- Severe congestive heart failure (NYHA III or IV)
- Subjects with known anaphylactic allergy to iodinated contrast
- Any active, serious, life-threatening disease with a life expectancy of less than 2 years
- Any active infection
- Known history of 2nd or 3rd degree heart block; sick sinus syndrome; long QT syndrome
- Impaired chronic renal function (EPI-GFR<30ml/min)
- Patient underwent coronary angiography or coronary CTA before the randomization
- Pregnancy or unknown pregnancy status in subject of childbearing potential
- Evidence of ongoing or active clinical instability, including acute chest pain (sudden onset), cardiogenic shock, unstable blood pressure with systolic blood pressure <90 mmHg, or acute pulmonary edema
- Inability to comply with study procedures
- Contraindication for guideline-guided long-term antiplatelet/anticoagulation regime after PCI/CABG
- Large neurologic deficit (Rankin scale >III)
Where in Latvia
- Pauls Stradins Clinical University HospitalRiga, LatviaContact: Dainis Krievins, MD, PhDTaking people
About the trial
What the trial wants to find out
The primary objective of this study is to determine whether among symptomatic and asymptomatic carotid artery stenosis (CAS) patients with no known coronary artery disease (CAD) who had undergone carotid artery revascularization (endarterectomy of stenting) a strategy of best medical therapy (BMT) plus selective coronary revascularization based on FFRct assessment of lesion-specific coronary ischemia can reduce adverse cardiac events and improve survival compared to BMT alone. Lesion-specific coronary ischemia is defined as FFRCT ≤0.80 distal to stenosis in a major (≥2 mm) coronary artery with severe ischemia defined as FFRCT ≤0.75.
The 2 groups in the trial
- Assigned to Best Medical Therapy (BMT) alone
Patients who have undergone successful carotid artery revascularization (endarterectomy of stenting) and are assigned to BMT alone within 14 days following revascularization.
- Assigned to Best Medical Therapy (BMT) + coronary CT angiography + CT-FFRct analysis
Patients who have undergone successful carotid artery revascularization (endarterectomy of stenting) and are assigned to BMT plus coronary CT angiography (which must be completed within 14 days of randomization) and FFRct analysis to determine the functional significance of coronary lesions identified on the CT scan.
Treatment: Coronary CT angiography and FFRct analysis
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial)
- Plain-language title
- Checking heart arteries with CT scans after neck artery treatmentGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 9 August 2024