Under construction – not a live service
Sign in
Taking people in ItalyNo phase

Robot-assisted versus traditional rehabilitation after stroke

Compares robot and digital rehabilitation with traditional therapy in adults recovering from stroke.

Plain-language title generated from the registry record
Registry title: Rehabilitation With and Without Robot and Allied Digital Technologies in Stroke Patients

Key facts

Where
Acerenza, Bari, Bergamo, Catania, Catanzaro, Crotone, Foggia, Genova, Messina, Milan, Montescano, Padova, Pavia, Pisa, Roma, Rozzano, Salerno, Sant'Angelo dei Lombardi, Sterzing, Telese Terme, Trento, Tricarico, and Venezia, ItalySee the 27 sites

Where in Italy

  • Fondazione Don Carlo Gnocchi, Centro GalaAcerenza, ItalyTaking people
  • IRCCS Istituti Clinici Scientifici MaugeriBari, ItalyTaking people
  • Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIIIBergamo, ItalyTaking people
  • Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"Catania, ItalyTaking people
  • Università degli Studi Magna Graecia di Catanzaro (A.O.U. "Renato Dulbecco" Catanzaro)Catanzaro, ItalyTaking people
  • Istituto S. Anna di Ezio Pugliese s.r.l.Crotone, ItalyTaking people
  • Università di Foggia (Azienda Ospedaliero-Universitaria "Policlinico Riuniti" - Foggia)Foggia, ItalyTaking people
  • IRCCS Ospedale Policlinico San MartinoGenova, ItalyTaking people
  • IRCCS Centro Neurolesi Bonino PulejoMessina, ItalyTaking people
  • Fondazione Don Carlo Gnocchi, IRCCS Santa Maria NascenteMilan, ItalyTaking people
  • IRCCS Istituti Clinici Scientifici MaugeriMilan, ItalyTaking people
  • IRCCS Istituti Clinici Scientifici MaugeriMontescano, ItalyTaking people
  • Università degli Studi di Padova (Azienda Ospedale Università di Padova)Padova, ItalyTaking people
  • IRCCS Fondazione MondinoPavia, ItalyTaking people
  • IRCCS Istituti Clinici Scientifici MaugeriPavia, ItalyTaking people
  • Università di Pisa (A.O.U. Pisana)Pisa, ItalyTaking people
  • Fondazione Don Carlo Gnocchi - Centro Santa Maria della ProvvidenzaRoma, ItalyTaking people
  • IRCCS San Raffaele Roma s.r.l.Roma, ItalyTaking people
  • Università Humanitas University - Hunimed (IRCCS Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.)Rozzano, ItalyTaking people
  • Fondazione Don Carlo Gnocchi, Centro Santa Maria al MareSalerno, ItalyTaking people
  • Università degli Studi di Salerno (Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona)Salerno, ItalyTaking people
  • Fondazione Don Carlo Gnocchi, Polo Specialistico RiabilitativoSant'Angelo dei Lombardi, ItalyTaking people
  • Azienda Sanitaria dell'Alto Adige - Ospedale di VipitenoSterzing, ItalyTaking people
  • IRCCS Istituti Clinici Scientifici MaugeriTelese Terme, ItalyTaking people
  • APSS TrentoTrento, ItalyTaking people
  • Fondazione Don Carlo Gnocchi, Polo specialistico riabilitativoTricarico, ItalyTaking people
  • San Camillo IRCCS s.r.l.Venezia, ItalyTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
Fondazione Don Carlo Gnocchi ETS
Trial code
NCT06547827
Record updated
24 July 2026
Original description
Rehabilitation after stroke often employs Robot and Allied Digital Technologies (RADTs), yet evidence on their effectiveness remains inconclusive due to study heterogeneity and limited sample sizes.Read full original descriptionShow less

Rehabilitation With and Without Robot and Allied Digital Technologies (RADTs) in Stroke Patients: a Pragmatic Multicenter Randomised Controlled Trial on the Effectiveness, Acceptability, Usability, and Economic-organizational Sustainability of RADTs From Subacute to Chronic Phase

Rehabilitation after stroke often employs Robot and Allied Digital Technologies (RADTs), yet evidence on their effectiveness remains inconclusive due to study heterogeneity and limited sample sizes.

This multicentre randomized controlled pragmatic trial aims at comprehensively and accurately assessing the effectiveness of rehabilitation mediated by RADTs after a stroke, compared to traditional rehabilitation, also considering economic sustainability.

Inclusion: First-ever diagnosis of ischemic or haemorrhagic stroke confirmed by Computed Tomography or Magnetic Resonance Imaging; Age 18 years and over; Time since the event equal to or less than 6 months; Mild to severe impairment of the upper limb (motor section of the Fugl-Meyer Assessment of Upper Extremity ≤ 58) and/or mild to severe impairment of the lower limb (score on the Functional Ambulation Categories scale ≤ 4) and/or mild to severe impairment of balance (Berg Balance Scale ≤ 45); Clinical stability allowing transfer to the gym and execution of the planned treatments.

Exclusion: Serious uncorrectable visual impairments preventing the patient from performing treatment with technological and/or robotic devices; Behavioral/cognitive disorders preventing adequate patient compliance with both traditional and robotic rehabilitation treatment (severe cognitive deficit, Montreal Cognitive Assessment <10); Clinical instability; Rigidity or hypertonia (Modified Ashworth Scale > 3) in the plegic/paretic limb; Pregnant women; Refusal to sign the informed consent.

ClinicalTrials.gov NCT06547827