Comparing two ways to treat paroxysmal atrial fibrillation with catheter ablation
Compares pulse field ablation with cryoablation in adults with paroxysmal atrial fibrillation.
Key facts
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Where
- Paris, FranceSee the site
- Trial code
- Registry title
- The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation
- Status
- Recruiting
- People taking part
- 80 people, planned
- Started
- 9 Oct 2024
- Planned end
- 1 Oct 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Pulmonary vein isolation by pulse field ablation
- Pulmonary vein isolation by cryoablation
- Record updated
- 2 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with paroxysmal atrial fibrillation who need catheter ablation. It compares pulse-field ablation with cryoablation.
- Age
- 18 years or older
- Sex
- Men and women can join.
- Disease stage
- Established paroxysmal atrial fibrillation with an indication for catheter ablation. An episode must be documented by ECG within the last 12 months.
- Earlier treatment
- People who had a previous ablation in the left atrium or previous heart surgery cannot join.
Main reasons for not taking part
- Atrial fibrillation that is not paroxysmal
- Blood clot inside the heart
- Significant heart valve disease
- Cannot have an MRI or the DOTAREM contrast product (for example pacemaker, severe kidney disease with GFR < 30 mL/min)
- Pregnant or breast-feeding
The registry criteria, word for word
Show all 17 criteriaShow less
Who can take part
- Patient age ≥ 18
- Established diagnosis of paroxysmal fibrillation, with a I/IIa/IIb indication for catheter ablation (ESC 2020 guidelines)
- Episode of AF documented by ECG within the last 12 months
- Patient able to give written informed consent
- If female of childbearing potential, have a negative serum pregnancy test and using effective contraception
- Be affiliated with a French social security system or entitled
Who cannot take part
- Previous ablation in the left atrium
- Previous heart surgery
- Participation in another interventional study or being in the exclusion period at the end of a previous study
- Significant valvular heart disease defined as any moderate (grade 3) or severe (grade 4) mitral regurgitation, mitral stenosis, aortic regurgitation, aortic stenosis, tricuspid regurgitation, or tricuspid stenosis
- Contraindication to perform MRI or using the DOTAREM™ contrast product (pacemaker, defibrillator, foreign body or prosthesis, old generation heart valves, old generation ferromagnetic vascular surgical clips, percutaneous devices for endocranial aneurysms, neurosimulator, cochlear implants, automated injection device such as insulin pump, and more generally any non-removable electronic device, severe kidney disease with GFR < 30 mL/min, documented hypersensitivity to gadoteric acid or to excipients, severe claustrophobia)
- Non-paroxysmal atrial fibrillation
- Contraindication to oral anticoagulation
- Intracardiac thrombus
- Patient on AME (state medical aid)
- Pregnant or breast-feeding female
- Patient protected by law (guardianship, tutelage measure, deprived of liberty)
Where in France
- Dr Mikael LaredoParis, FranceContact: LAREDOTaking people
About the trial
What the trial wants to find out
The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation. The main question it aims to answer is:
Read full original descriptionShow less
• Is catheter ablation energy (pulse field ablation) revealing a better preservation of the atrial function architecture than with conventional catheter ablation technologies ?
Participants will performed 2 IRMs with injection and completed Quality of Life Questionnaires. They participate in the study for 4 months.
Researchers will compare 2 arms:
* Pulse-Field Ablation * Cryoablation
The 2 groups in the trial
- Pulmonary vein isolation by pulse field ablationExisting treatment, for comparison
- Pulmonary vein isolation by cryoablationExisting treatment, for comparison
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Pulse Field Ablation on Atrial Mechanics Assessed by MRI and on Patient-related Outcomes in Catheter Ablation of Paroxysmal Atrial Fibrillation
- Plain-language title
- Comparing two ways to treat paroxysmal atrial fibrillation with catheter ablationGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 2 June 2026