Physical Exercise to Support Thinking Skills in Bipolar Disorder
Tests physical exercise alongside usual care in adults with bipolar disorder and thinking difficulties.
Plain-language title generated from the registry record
Registry title: Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder
Key facts
- Where
- São Paulo, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT06560749, who can take part
Where in Brazil
- Gabriel Okawa BelizarioSão Paulo, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beny Lafer
- Trial code
- NCT06560749
- Record updated
- 16 July 2026
- Original description
The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables.Read full original descriptionShow less
Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder: a Controlled and Randomized Study
The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables.
Our specific goals are:
1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.
Inclusion: Diagnosis of Bipolar disorder (BD) I and II according to DSM-5; Age: 18 - 55 years old; Complete primary education; Euthymic (YMRS < 8 and MADRS < 12); Presence of cognitive impairments (COBRA > 14 and SCIP < 75); Estimated IQ ≥ 80; No medication changes in the last month; Having been without regular PE practice for six months; Signature of the TCLE.
Exclusion: Alcohol or drug abuse in the last 6 months; Organic mental disorder; BMI > 40; Use of benzodiazepines or beta-blockers in the last month.