Tracks death and heart disease risk in adults with late-onset type 1 diabetes
Follows adults with type 1 diabetes diagnosed later in life, comparing death and heart disease.
Plain-language title generated from the registry record
Registry title: Mortality and Cardiovascular Diseases in Adult-onset Type 1 Diabetes
Key facts
- Where
- Stockholm, SwedenSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 110 years old?
Source: NCT06563401, who can take part
Where in Sweden
- Karolinska InstituteStockholm, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Karolinska Institutet
- Trial code
- NCT06563401
- Record updated
- 3 April 2025
- Original description
Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics that contribute to T1D prognosis. In addition, we will estimate the life expectancy associated with different age at T1D diagnosis as compared to population controls. This study will be based on people with diabetes recorded in Swedish National Diabetes Registers, with linkages to other nationwide registers to retrieve data on lifestyle factors, biomarkers, treatment and outcome information.Read full original descriptionShow less
Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 Diabetes
Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics that contribute to T1D prognosis. In addition, we will estimate the life expectancy associated with different age at T1D diagnosis as compared to population controls. This study will be based on people with diabetes recorded in Swedish National Diabetes Registers, with linkages to other nationwide registers to retrieve data on lifestyle factors, biomarkers, treatment and outcome information.
Inclusion: people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register; all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register; Everyone with T1D was matched by age, sex, and county to 50 population controls from the Total Population Register.
Exclusion: To avoid diabetes secondary to pancreatic cancer, we excluded people diagnosed with cancer in the digestive system 1 year prior to diabetes diagnosis and with pancreatic cancer as the underlying cause of death.